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  2. Assessing and Managing Chemicals under TSCA

Risk Evaluation for Ethylene Dibromide

General Information for Ethylene Dibromide

Chemical Group: Solvents

CASRN: 106-93-4

Risk Evaluation Initiated: December 2019

Docket: EPA-HQ-OPPT-2018-0488

Staff Contact: Bethany Masten
EthyleneDibromide.TSCA@epa.gov
(202) 564-8803

In August 2026, EPA released the draft risk evaluation and associated technical support documents for ethylene dibromide under the Toxic Substances Control Act (TSCA) for public comment.

EPA will accept public comments on the draft risk evaluation for 60 days in the ethylene dibromide TSCA docket (EPA-HQ-OPPT-2018-0488) at www.regulations.gov. 

EPA designated ethylene dibromide as a High-Priority Substance in December 2019 and the chemical is currently undergoing risk evaluation. 

Find other information about other chemicals undergoing risk evaluations under TSCA. 

On this page:

  • What is Ethylene Dibromide?
  • Draft Risk Evaluation for Ethylene Dibromide
  • Draft Risk Evaluation and Supporting Documents

What is Ethylene Dibromide?

Ethylene dibromide (CASRN 106-93-4) is a colorless liquid. The primary use of ethylene dibromide is as a fuel additive. Information from the 2016 Chemical Data Reporting (CDR) for ethylene dibromide indicates the reported production volume is between 1 million and 20 million lbs/year (manufacture and import).

Draft Risk Evaluation for Ethylene Dibromide

EPA's draft risk evaluation for ethylene dibromide identifies significant contributions to unreasonable risk to workers and occupational non-users driven by inhalation and dermal exposures under multiple conditions of use. The draft risk evaluation did not find unreasonable risk to consumers, the general population or the environment. 

Using chemical-specific monitoring data, exposure modeling, and systematic review of the health literature, EPA preliminarily identified unreasonable risk to workers from non-cancer and cancer risk associated with inhalation and dermal exposure across 10 of the 12 conditions of use assessed, including four conditions of use that also present non-cancer and cancer risk to occupational non-users through inhalation exposure. 

EPA will move quickly, after public comment, to finalize the risk evaluation. Should EPA continue to find unreasonable risk, EPA will then propose risk management actions under TSCA to address these unsafe workplace exposures.

EPA emphasizes that this evaluation is draft and does not represent a final Agency determination regarding the risks posed by this chemical. The findings and conclusions may change based on feedback received during the public comment period. Additionally, the release of a draft evaluation does not alter or impact any existing protections, regulations, or risk management measures currently in place for this chemical. All current safeguards remain in place.

Draft Risk Evaluation and Supporting Documents

View the Federal Register Notice and supporting documents in EPA-HQ-OPPT-2018-0488. 

  • Draft Risk Evaluation for Ethylene Dibromide (pdf) (3.78 MB)
  • Draft Chemistry, Fate, Release, and Exposure Assessment for Ethylene Dibromide (pdf) (5.36 MB)
  • Draft Hazard Assessment for Ethylene Dibromide (pdf) (5.52 MB)
  • Draft Systematic Review Protocol for Ethylene Dibromide (pdf) (1.94 MB)
  • Draft Data Quality Evaluation and Data Extraction Information for Physical and Chemical Properties for Ethylene Dibromide (pdf) (877.95 KB)
  • Draft Data Quality Evaluation and Data Extraction Information for Environmental Fate and Transport for Ethylene Dibromide (pdf) (1.15 MB)
  • Draft Data Quality Evaluation and Data Extraction Information for Environmental Release and Occupational Exposure for Ethylene Dibromide (pdf) (1.01 MB)
  • Draft Data Quality Evaluation Information for Dermal Absorption for Ethylene Dibromide (pdf) (154.66 KB)
  • Draft Data Quality Evaluation Information for General Population, Consumer, and Environmental Exposure for Ethylene Dibromide (pdf) (359.43 KB)
  • Draft Data Extraction Information for General Population, Consumer, and Environmental Exposure for Ethylene Dibromide (pdf) (160.77 KB)
  • Draft Data Quality Evaluation Information for Human Health Hazard Epidemiology for Ethylene Dibromide (pdf) (463.51 KB)
  • Draft Data Quality Evaluation Information for Human Health Hazard Animal Toxicology for Ethylene Dibromide (pdf) (1.46 MB)
  • Draft Data Quality Evaluation Information for Environmental Hazard for Ethylene Dibromide (pdf) (2.37 MB)
  • Draft Data Extraction Information for Environmental Hazard and Human Health Hazard Animal Toxicology and Epidemiology for Ethylene Dibromide (pdf) (1.7 MB)
  • Draft Exposure and Fate Assessment Screening Tool (E-FAST) Surface Water Concentrations for Ethylene Dibromide (xlsx) (54.29 KB)
  • Draft Point Source Calculator (PSC) Surface Water Concentrations for Ethylene Dibromide (pdf) (159.23 KB)
  • Draft Number of Sites for Ethylene Dibromide (xlsx) (276.78 KB)
  • Draft Water Releases for Ethylene Dibromide (xlsx) (90.49 KB)
  • Draft Air Releases for Ethylene Dibromide (xlsx) (9.07 MB)
  • Draft Default Risk Calculator for Occupational and Consumer Exposures for Ethylene Dibromide (xlsx) (240.12 KB)
  • Draft PBPK Risk Calculator for Occupational Exposures for Ethylene Dibromide (xlsx) (183.44 KB)
  • Draft Calculations for Estimating Vapor Fraction of Ethylene Dibromide VOC in 100LL Avgas (xlsx) (60.24 KB)
  • Draft Estimates for Number of Workers and ONUs for Ethylene Dibromide (xlsx) (3.43 MB)
  • Draft Human Exposure Model (HEM) Exposure and Risk Calculator for General Population for Ethylene Dibromide (pdf) (162.48 KB)
  • Draft Integrated Indoor Outdoor Air Calculator (IIOAC) Exposure and Risk Calculator for General Population for Ethylene Dibromide (xlsx) (129.63 KB)
  • Draft Surface Water Human Exposure Risk Calculator for Ethylene Dibromide (xlsx) (139.44 KB)
  • Draft Fish Ingestion Risk Calculator for General Population Exposure for Ethylene Dibromide (xlsx) (62.53 KB)
  • Draft Summary of AMTIC Data of Ethylene Dibromide 2017-2022 (xlsx) (435.08 KB)
  • Draft Evaluation of PBPK Model for Ethylene Dibromide (pdf) (2.33 MB)
  • Draft Import and Repackaging Release Model for Ethylene Dibromide (xlsx) (73.64 KB)
  • Draft Fuels and Related Products Release Model for Ethylene Dibromide (xlsx) (69.71 KB)
  • Draft IH SkinPerm Dermal Absorption Modeling for Ethylene Dibromide (xlsx) (317.99 KB)
  • Draft PBPK Model Code and Data for Ethylene Dibromide (pdf) (159.61 KB)

Assessing and Managing Chemicals under TSCA

  • How EPA Evaluates the Safety of Existing Chemicals
  • Prioritizing Existing Chemicals for Risk Evaluation
  • Risk Evaluations for Existing Chemicals under TSCA
  • Risk Management for Existing Chemicals under TSCA
Assessing and Managing Chemicals under TSCA Contact Us
Assessing and Managing Chemicals under TSCA Contact Us to ask a question, provide feedback, or report a problem.
Last updated on August 18, 2026
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