Now Available: Latest Update to the TSCA Inventory

Released August 14, 2025

The U.S. Environmental Protection Agency (EPA) has released the latest Toxic Substances Control Act (TSCA) Inventory, with the public portion available on EPA’s website.

The TSCA Inventory is a list of all existing chemical substances manufactured, processed or imported in the U.S. under TSCA that do not otherwise qualify for an exemption or exclusion. This biannual update to the TSCA Inventory includes EPA’s regular posting of non-confidential TSCA Inventory data. The next regular update of the TSCA Inventory is planned for winter 2026.  

EPA is also updating the TSCA Master Inventory File, which includes the full, specific chemical identities claimed as confidential. The TSCA Master Inventory File now contains 86,862 chemicals of which 42,578 are active (currently known to be in use) in U.S. commerce. Other updates to the TSCA Inventory include updates to commercial activity data, unique identifier data and to regulatory flags (e.g., Significant New Use Rules and test orders).

EPA continues to perform ongoing CBI reviews resulting in a number of chemicals that no longer have confidential claims to the chemical name and have been moved to the non-confidential portion of the Inventory.

For more information on the TSCA Inventory, please visit EPA’s website.