2026 Human Health Benchmarks for Pharmaceuticals (HHB-Rx)
The U.S. Environmental Protection Agency (EPA), in coordination with the Federal Workgroup on Pharmaceuticals in Water, including the U.S. Department of Agriculture (USDA), U.S. Food and Drug Administration (FDA), and U.S. Geological Survey (USGS), developed human health benchmarks for pharmaceuticals (HHB-Rx) that are approved by the FDA and may occur in source waters (surface and groundwater) and/or treated drinking water. To develop each benchmark, EPA used the lowest oral therapeutic dose from FDA approved labels.
In April 2026, EPA released 374 HHB-Rxs. The HHB-Rx table includes two benchmark values for each pharmaceutical: one for the general population (all ages) and one for infants. EPA may update the HHB-Rx as FDA drug labels change and add benchmarks for additional pharmaceuticals in the future as warranted.
For additional drug label information, please see the linked drug label in the first column and/or the HHB-Rx Technical Support Appendix: Human Health Benchmarks for Pharmaceuticals: 2026 Technical Support Appendix (xlsx) .
| Active Pharmaceutical Ingredient (API) | Lowest Daily Dose (LDD) (mg/day) | Lowest Therapeutic Dose (LTD) (mg/kg-day) | Screening Dose (mg/kg-day) | Infant Benchmark (ug/L) | General Population Benchmark (ug/L) | LDD Label Information | Label Date Used |
|---|---|---|---|---|---|---|---|
| Abacavir | 600 | 7.5 | 0.003 | 14.0 | 59.2 | The recommended dosage of abacavir tablets for adults is 600 mg daily. | 8-Jan-21 |
| Acarbose | 75 | 0.9 | 0.0003 | 1.7 | 7.4 | The recommended starting dosage of acarbose tablets is 25 mg given orally three times daily at the start (with the first bite) of each main meal. | 16-Sep-20 |
| Acebutolol | 200 | 2.5 | 0.001 | 4.7 | 19.7 | An optimal response is usually achieved with dosages of 400 to 800 mg per day, although some patients have been maintained on as little as 200 mg per day. | 27-Dec-20 |
| Acetaminophen | 2600 | 32.5 | 0.01 | 60.6 | 256.4 | Adults and children 12 year of age and over: take two 325-mg tablets every 4 to 6 hours while symptoms persist. | 29-Nov-19 |
| Acetylcysteine | 6600 | 82.5 | 0.03 | 153.8 | 650.9 | Oral administration requires dilution of the 20% solution with diet cola, or other diet soft drinks, to a final concentration of 5%. Dosage table shows a body weight of 80-89 kg receives a maintenance dose of 33 mL of 20% solution. The label shows that 1 mL contains 200 mg of acetylcysteine. | 31-Aug-20 |
| Acetylsalicylic acid | 162.5 | 2.0 | 0.001 | 3.8 | 16.0 | The recommended dose of acetylsalicylic acid is one capsule (162.5 mg) once daily. | 25-Sep-15 |
| Acitretin | 25 | 0.3 | 0.0001 | 0.6 | 2.5 | Maintenance doses of 25 to 50 mg per day may be given dependent upon an individual patient’s response to initial treatment. | 29-Dec-20 |
| Acyclovir | 600 | 7.5 | 0.003 | 14.0 | 59.2 | 400 mg 2 times daily for up to 12 months, followed by re-evaluation. Alternative regimens have included doses ranging from 200 mg 3 times daily to 200 mg 5 times daily. | 6-Sep-13 |
| Albuterol | 6 | 0.1 | 0.00003 | 0.1 | 0.6 | The usual starting dosage for adults and children 12 years and older is 2 or 4 mg three or four times a day. | 30-Jul-20 |
| Alendronate | 5 | 0.1 | 0.00002 | 0.1 | 0.5 | The recommended dosage is one 5 mg tablet once daily for prevention of osteoporosis in postmenopausal women. | 28-Dec-21 |
| Alfuzosin | 10 | 0.1 | 0.00004 | 0.2 | 1.0 | The recommended dosage is one 10 mg alfuzosin hydrochloride extended-release tablet once daily. | 6-Oct-20 |
| Allopurinol | 100 | 1.3 | 0.0004 | 2.3 | 9.9 | The minimal effective dosage is 100 to 200 mg daily and the maximal recommended dosage is 800 mg daily. | 18-Nov-21 |
| Alprazolam | 0.75 | 0.009 | 0.000003 | 0.02 | 0.1 | Treatment for patients with anxiety should be initiated with a dose of 0.25 to 0.5 mg given three times daily. | 28-Feb-17 |
| Amantadine | 200 | 2.5 | 0.001 | 4.7 | 19.7 | The adult daily dosage of amantadine hydrochloride capsules is 200 mg. | 30-Sep-21 |
| Amiloride | 5 | 0.1 | 0.00002 | 0.1 | 0.5 | If it is necessary to use amiloride HCl tablets alone, the starting dosage should be one 5 mg tablet daily. This dosage may be increased to 10 mg per day, if necessary. | 21-Dec-21 |
| Aminosalicylic acid | 12000 | 150.0 | 0.1 | 279.7 | 1183.4 | The adult dosage of four grams (one packet) three times per day should be given by sprinkling on apple sauce or yogurt or by swirling in the glass to suspend the granules in an acidic drink such as tomato or orange juice. | 1-Jun-10 |
| Amiodarone | 400 | 5.0 | 0.002 | 9.3 | 39.4 | When adequate arrhythmia control is achieved, or if side effects become prominent, amiodarone dose should be reduced to 600 to 800 mg/day for one month and then to the maintenance dose, usually 400 mg/day. | 15-Dec-21 |
| Amitriptyline | 40 | 0.5 | 0.0002 | 0.9 | 3.9 | The usual maintenance dosage of amitriptyline HCl is 50 to 100 mg per day. In some patients, 40 mg per day is sufficient. | 23-Oct-19 |
| Amlodipine | 5 | 0.1 | 0.00002 | 0.1 | 0.5 | The usual initial antihypertensive oral dose of amlodipine is 5 mg once daily with a maximum dose of 10 mg once daily. | 15-Dec-08 |
| Amoxicillin | 750 | 9.4 | 0.003 | 17.5 | 74.0 | Usual adult dose for most infections is 500 mg every 12 hours or 250 mg every 8 hours. | 19-May-08 |
| Amphetamine | 2 | 0.03 | 0.00001 | 0.05 | 0.2 | In patients 6 years of age and older, start with 2.5 mg or 5 mg once daily in the morning. The dose may be increased in increments of 2.5 mg to 10 mg per day every 4 to 7 days up to a maximum dose of 20 mg per day. Each 5 mg strength tablet contains 4 mg of amphetamine. | 17-Dec-21 |
| Amphetamine sulfate | 5 | 0.1 | 0.00002 | 0.1 | 0.5 | Usual dose is 5 to 60 milligrams per day in divided doses depending on the individual patient response. | 27-Dec-21 |
| Ampicillin | 1000 | 12.5 | 0.004 | 23.3 | 98.6 | For respiratory tract infections, the usual dose is 250 mg to 500 mg every 6 hours. | 17-Dec-21 |
| Anastrozole | 1 | 0.01 | 0.000004 | 0.02 | 0.1 | The dose of anastrozole tablet is one 1 mg tablet taken once a day. | 21-Oct-20 |
| Aripiprazole | 10 | 0.1 | 0.00004 | 0.2 | 1.0 | The recommended starting and target dose for aripiprazole is 10 mg/day or 15 mg/day administered on a once-a-day schedule without regard to meals. | 21-Jul-21 |
| Artemether | 160 | 2.0 | 0.0007 | 3.7 | 15.8 | Artemether is given in combination with lumefantrine in a tablet form (COARTEM tablets). COARTEM tablets should be administered over 3 days for a total of 6 doses: an initial dose, second dose after 8 hours, and then twice-daily (morning and evening) for the following 2 days. The adult dosage for patients with bodyweight of 35 kg and above is 4 COARTEM tablets per dose for a total of 6 doses over 3 days. COARTEM tablets are scored and contain 20 mg artemether and 120 mg lumefantrine. | 7-Jun-22 |
| Atenolol | 50 | 0.6 | 0.0002 | 1.2 | 4.9 | The initial dose of atenolol is 50 mg given as one tablet a day either alone or added to diuretic therapy. | 10-Jul-07 |
| Atorvastatin | 10 | 0.1 | 0.00004 | 0.2 | 1.0 | The dosage range of atorvastatin calcium tablets is 10 to 80 mg once daily. | 30-Nov-20 |
| Atropine | 0.02 | 0.0003 | 0.00000008 | 0.0005 | 0.002 | Atropine sulfate is given in combination with diphenoxylate hydrochloride in a tablet form as Lomotil. Each Lomotil tablet contains 2.5 mg of diphenoxylate hydrochloride USP (equivalent to 2.3 mg of diphenoxylate) and 0.025 mg of atropine sulfate USP (equivalent to 0.01 mg of atropine). The initial adult dosage is 2 Lomotil tablets four times daily. After initial control has been achieved, the Lomotil dosage may be reduced to meet individual requirements. Control may often be maintained with as little as two Lomotil tablets daily. | 25-Oct-21 |
| Azathioprine ҂ | 80 | 1.0 | 0.0003 | 1.9 | 7.9 | Azathioprine is usually given on a daily basis. The initial dose should be approximately 1 mg/kg (50 to 100 mg) given as a single dose or on a twice-daily schedule. | 30-Nov-21 |
| Azithromycin | 250 | 3.1 | 0.001 | 5.8 | 24.7 | The recommended dose is 500 mg as a single daily dose by the intravenous route for one or two days, followed by 250 mg once daily by the oral route to complete a 7 day course of therapy. | 20-Aug-20 |
| Baclofen | 40 | 0.5 | 0.0002 | 0.9 | 3.9 | Start therapy at a low dosage and increase gradually until optimum effect is achieved (usually between 40-80 mg daily). | 30-Mar-07 |
| Benazepril | 20 | 0.3 | 0.00008 | 0.5 | 2.0 | The usual maintenance dosage range is 20-40 mg per day administered as a single dose or in two equally divided doses. A dose of 80 mg gives an increased response, but experience with this dose is limited. | 28-Mar-07 |
| Bendroflumethiazide | 5 | 0.1 | 0.00002 | 0.1 | 0.5 | Bendroflumethiazide is given in combination with nadolol in a tablet. Each tablet contains 40 mg or 80 mg nadolol combined with 5 mg bendroflumethiazide. Bendroflumethiazide is usually given at a dose of 5 mg daily. | 15-Apr-16 |
| Benzonatate | 300 | 3.8 | 0.001 | 7.0 | 29.6 | For adults and children over 10 years of age, the usual dose is one 100 mg, 150 mg, or 200 mg capsule three times a day as needed for cough. | 14-Jan-20 |
| Benztropine | 0.5 | 0.006 | 0.000002 | 0.01 | 0.05 | The usual daily dose for benztropine mesylate is 1 to 2 mg, with a range of 0.5 to 6 mg orally. | 1-May-20 |
| Betaxolol | 10 | 0.1 | 0.00004 | 0.2 | 1.0 | The initial dose of betaxolol tablets in hypertension is ordinarily 10 mg once daily either alone or added to diuretic therapy. If the desired response is not achieved the dose can be doubled after 7 to 14 days. | 9-Nov-20 |
| Bicalutamide | 50 | 0.6 | 0.0002 | 1.2 | 4.9 | The recommended dose for bicalutamide tablets therapy in combination with an LHRH analog is one 50 mg tablet once daily (morning or evening), with or without food. | 12-Aug-19 |
| Bisoprolol | 2.5 | 0.03 | 0.00001 | 0.1 | 0.2 | The usual starting dose of bisoprolol fumarate is 5 mg once daily. In some patients, 2.5 mg may be an appropriate starting dose. If the antihypertensive effect of 5 mg is inadequate, the dose may be increased to 10 mg and then, if necessary, to 20 mg once daily. | 14-Oct-19 |
| Bromocriptine | 2.5 | 0.03 | 0.00001 | 0.1 | 0.2 | The initial dosage of bromocriptine mesylate tablets in adults is one-half to one 2.5 mg scored tablet daily. An additional 2.5 mg tablet may be added to the treatment regimen as tolerated every 2-7 days until an optimal therapeutic response is achieved. The therapeutic dosage ranged from 2.5-15 mg daily in adults studied clinically. | 4-May-07 |
| Budesonide | 6 | 0.1 | 0.00003 | 0.1 | 0.6 | The recommended dosage in adults, following an 8 week course(s) of treatment for active disease and once the patient’s symptoms are controlled (CDAI less than 150), is budesonide capsules (enteric coated) 6 mg orally once daily for maintenance of clinical remission up to 3 months. | 5-Mar-14 |
| Buprenorphine | 4 | 0.1 | 0.00002 | 0.1 | 0.4 | The maintenance dose is generally in the range of 4 mg to 24 mg buprenorphine per day depending on the individual patient. | 31-Aug-21 |
| Bupropion | 300 | 3.8 | 0.001 | 7.0 | 29.6 | Initiate dosing with 150 mg per day given as a single daily dose in the morning. After 3 days of dosing, the dose may be increased to the 300 mg/day target dose, given as 150 mg twice daily. | 4-Nov-20 |
| Buspirone | 15 | 0.2 | 0.00006 | 0.3 | 1.5 | The recommended initial dose is 15 mg daily (7.5 mg b.i.d.). To achieve an optimal therapeutic response, at intervals of 2 to 3 days the dosage may be increased 5 mg per day, as needed. The maximum daily dosage should not exceed 60 mg per day. In clinical trials allowing dose titration, divided doses of 20 mg to 30 mg per day were commonly employed. | 27-May-21 |
| Busulfan | 1 | 0.01 | 0.000004 | 0.02 | 0.1 | Busulfan is administered orally. The usual adult dose range for remission induction is 4 to 8 mg, total dose, daily. When remission is shorter than 3 months, maintenance therapy of 1 to 3 mg daily may be advisable in order to keep the hematological status under control and prevent rapid relapse. | 30-May-21 |
| Butalbital | 300 | 3.8 | 0.001 | 7.0 | 29.6 | Butalbital is given in combination with acetaminophen, caffeine, and codeine phosphate in a capsule. Capsules contain 50 mg butalbital, 325 mg acetaminophen, 40 mg caffeine, and 30 mg codeine phosphate. Initiate treatment with one or two capsules every 4 hours. Total daily dosage should not exceed 6 capsules. | 9-Mar-21 |
| Caffeine | 130 | 1.6 | 0.0005 | 3.0 | 12.8 | Caffeine is given in combination with acetaminophen and aspirin in a tablet. Adults: take 2 tablets with a glass of water; do not take more than 2 tablets in 24 hours. Each tablet has 65 mg of caffeine. | 11-May-23 |
| Candesartan cilexetil | 8 | 0.1 | 0.00003 | 0.2 | 0.8 | Blood pressure response is dose related over the range of 2 to 32 mg. Candesartan cilexetil tablets can be administered once or twice daily with total daily doses ranging from 8 mg to 32 mg. | 27-Jun-17 |
| Capecitabine | 5000 | 62.5 | 0.02 | 116.6 | 493.1 | The recommended dose of capecitabine tablets is 1250 mg/m2 administered orally twice daily (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1-week rest period given as 3-week cycles. The daily dose is 3000 mg/day based on a BSA of ≤ 1.25, and 5000 mg/day based on a BSA of 1.92-2.05. | 27-Jan-22 |
| Captopril | 50 | 0.6 | 0.0002 | 1.2 | 4.9 | The initial dose of captopril tablets is 25 mg b.i.d. or t.i.d. If satisfactory reduction of blood pressure has not been achieved after one or two weeks, the dose may be increased to 50 mg b.i.d. or t.i.d. | 26-Jun-14 |
| Carbamazepine | 200 | 2.5 | 0.001 | 4.7 | 19.7 | Control of pain can be maintained in most patients with 400 to 800 mg daily. However, some patients may be maintained on as little as 200 mg daily. | 29-Jan-08 |
| Carbidopa | 70 | 0.9 | 0.0003 | 1.6 | 6.9 | Most patients respond to a 1:10 proportion of carbidopa and levodopa, provided the daily dosage of carbidopa is 70 mg or more a day. | 2-Jul-20 |
| Carisoprodol | 1000 | 12.5 | 0.004 | 23.3 | 98.6 | The recommended dose of carisoprodol tablets is 250 mg to 350 mg three times a day and at bedtime. | 29-Oct-15 |
| Carvedilol | 12.5 | 0.2 | 0.00005 | 0.3 | 1.2 | Recommended starting dose is 6.25 mg twice daily; label indicates that the dose should only be increased up to 12.5 mg twice daily, if tolerated and needed, then again to the target dose of 25 mg twice daily. A lower starting dose may be used (3.125 mg twice daily) and/or the rate of up-titration may be slowed if clinically indicated. | 6-Oct-07 |
| Cefaclor | 750 | 9.4 | 0.003 | 17.5 | 74.0 | The usual adult dosage is 250 mg every 8 hours. | 18-Nov-20 |
| Cefadroxil | 1000 | 12.5 | 0.004 | 23.3 | 98.6 | For uncomplicated lower urinary tract infections (i.e., cystitis) the usual dosage is 1 or 2 g per day in a single (q.d.) or divided doses (b.i.d.). | 6-Sep-19 |
| Cefdinir | 600 | 7.5 | 0.003 | 14.0 | 59.2 | The total daily dose for all infections is 600 mg. | 12-Nov-21 |
| Cefixime | 400 | 5.0 | 0.002 | 9.3 | 39.4 | The recommended dose of cefixime is 400 mg daily. | 2-Jan-20 |
| Cefprozil | 500 | 6.3 | 0.002 | 11.7 | 49.3 | Administered orally at 500 mg/day or 250 mg b.i.d. | 12-May-16 |
| Cefuroxime | 500 | 6.3 | 0.002 | 11.7 | 49.3 | For pharyngitis/tonsillitis (mild to moderate), dosage is 250 mg every 12 hours. | 21-Oct-21 |
| Celecoxib | 200 | 2.5 | 0.001 | 4.7 | 19.7 | The dosage is 200 mg per day administered as a single dose or as 100 mg twice daily. | 24-Mar-21 |
| Cephalexin | 1000 | 12.5 | 0.004 | 23.3 | 98.6 | The usual adult dose is 250 mg every 6 hours. For some infections, a dosage of 500 mg may be administered every 12 hours. | 29-Aug-11 |
| Cetirizine | 5 | 0.1 | 0.00002 | 0.1 | 0.5 | For adults and children 6 years and over, take one 10 mg capsule once daily; do not take more than one 10 mg capsule in 24 hours. A 5 mg product may be appropriate for less severe symptoms. | 26-Jan-21 |
| Chlorhexidine | 36 | 0.5 | 0.0002 | 0.8 | 3.6 | Strength is 1.2 mg in 1 mL. Recommended use is twice daily rinsing for 30 seconds, morning and evening after tooth brushing. Usual dosage is 15 mL (marked in cap) of undiluted chlorhexidine gluconate oral rinse. | 2-Apr-19 |
| Chloroquine | 42.86 | 0.5 | 0.0002 | 1.0 | 4.2 | The adult dose is 500 mg tablet of chloroquine phosphate administered once per week on exactly the same day of each week. Each 500 mg tablet of chloroquine phosphate contains the equivalent of 300 mg chloroquine base. | 21-Jan-22 |
| Chlorothiazide | 500 | 6.3 | 0.002 | 11.7 | 49.3 | The usual adult dosage is 0.5 g to 1 g once or twice a day. | 21-Jan-20 |
| Chlorpheniramine | 16 | 0.2 | 0.00007 | 0.4 | 1.6 | Adults and children 12 years of age and older take one (4-mg chlorpheniramine maleate) tablet every 4 to 6 hours, not to exceed 6 tablets in 24 hours. | 15-Nov-11 |
| Chlorpromazine | 30 | 0.4 | 0.0001 | 0.7 | 3.0 | The dose for outpatients is 10 mg t.i.d. or q.i.d., or 25 mg b.i.d. or t.i.d. | 27-Jan-20 |
| Chlorthalidone | 15 | 0.2 | 0.0001 | 0.3 | 1.5 | Therapy in most patients should be initiated with a single daily dose of 15 mg. If the response is insufficient after a suitable trial, the dosage may be increased to 25 mg and then to a single daily dose of 30-50 mg or 100 mg once daily. Maintenance doses may often be lower than initial doses. | 20-Aug-19 |
| Cimetidine | 200 | 2.5 | 0.0008 | 4.7 | 19.7 | To relieve symptoms, adults and children 12 years and over swallow one (200 mg cimetidine) tablet; do not take more than 2 tablets in 24 hours. | 20-May-21 |
| Cinacalcet | 30 | 0.4 | 0.0001 | 0.7 | 3.0 | Starting dose is 30 mg once daily. Titrate dose no more frequently than every 2 to 4 weeks through sequential doses of 30, 60, 90, 120, and 180 mg once daily as necessary to achieve targeted intact parathyroid hormone (iPTH) levels. | 5-Dec-19 |
| Cinoxacin | 250 | 3.1 | 0.001 | 5.8 | 24.7 | For preventive therapy, a single dose of 250 mg at bedtime for up to 5 months has been shown to be effective in women with a history of recurrent urinary tract infections. | 23-Jun-99 |
| Ciprofloxacin | 200 | 2.5 | 0.0008 | 4.7 | 19.7 | For urinary tract infection (acute, uncomplicated), dose is 100 mg or 250 mg q 12 h for 3 days and for mild/moderate urinary tract infection, 250 mg, q 12h for 7-14 days. There are also indications for a single dose of 250 mg for other infections. | 12-Feb-10 |
| Citalopram | 20 | 0.3 | 0.00008 | 0.5 | 2.0 | Administer citalopram tablets once daily, with or without food, at an initial dosage of 20 mg once daily, with an increase to a maximum dosage of 40 mg once daily at an interval of no less than one week. | 19-Oct-21 |
| Clarithromycin | 500 | 6.3 | 0.002 | 11.7 | 49.3 | The recommended dosages of clarithromycin tablets for the treatment of most mild to moderate infections in adults is 250 to 500 mg every 12 hours. | 10-Dec-19 |
| Clavulanate | 250 | 3.1 | 0.001 | 5.8 | 24.7 | Clavulanate is given in combination with amoxicillin in a tablet as AUGMENTIN. The usual adult dose is one 500-mg tablet of AUGMENTIN every 12 hours or one 250-mg tablet of AUGMENTIN every 8 hours. Both the 250-mg and 500-mg tablets of AUGMENTIN contain the same amount of clavulanic acid (125 mg, as the potassium salt). | 22-Nov-10 |
| Clemastine | 2 | 0.025 | 0.000008 | 0.047 | 0.2 | Tablets contain 1.34 mg clemastine fumarate (equivalent to 1 mg clemastine). Adults and children 12 years and older take 1 tablet every 12 hours; not more than 2 tablets in 24 hours. | 21-May-12 |
| Clindamycin | 600 | 7.5 | 0.003 | 14.0 | 59.2 | For adults with serious infections, 150 to 300 mg every 6 hours. For adults with more severe infections, 300 to 450 mg every 6 hours. | 26-Sep-20 |
| Clomipramine | 100 | 1.3 | 0.0004 | 2.3 | 9.9 | Treatment with clomipramine hydrochloride capsules should be initiated at a dosage of 25 mg daily and gradually increased, as tolerated, to approximately 100 mg during the first 2 weeks. The dosage may be increased gradually over the next several weeks, up to a maximum of 250 mg daily. | 15-May-19 |
| Clonazepam | 1 | 0.01 | 0.000004 | 0.02 | 0.1 | The initial dose for adults with panic disorder is 0.25 mg b.i.d. An increase to the target dose for most patients of 1 mg/day may be made after 3 days. The recommended dose of 1 mg/day is based on the results from a fixed dose study in which the optimal effect was seen at 1 mg/day. | 18-Mar-08 |
| Clonidine | 0.2 | 0.003 | 0.0000008 | 0.005 | 0.02 | Dosing should be initiated with one 0.1 mg tablet at bedtime, and then taken twice a day (0.1 mg in the morning and 0.1 mg at bedtime); the daily dosage should be adjusted in increments of 0.1 mg/day at weekly intervals until the desired response is achieved. | 30-Sep-16 |
| Clopidogrel | 75 | 0.9 | 0.0003 | 1.7 | 7.4 | In patients who need an antiplatelet effect within hours, initiate clopidogrel tablets with a single 300-mg oral loading dose and then continue at 75 mg once daily. Otherwise, the dose is 75 mg once daily orally without a loading dose. | 28-Apr-21 |
| Clorazepate | 7.5 | 0.1 | 0.00003 | 0.2 | 0.7 | After the initial dose, the response of the patient may require adjustment of subsequent dosage. Gradually reduce the daily dose to 7.5 mg to 15 mg. | 30-Jun-20 |
| Clotrimazole | 50 | 0.6 | 0.0002 | 1.2 | 4.9 | The recommended dose is one (10-mg clotrimazole) lozenge five times a day for fourteen consecutive days. | 13-Dec-21 |
| Clozapine | 300 | 3.8 | 0.001 | 7.0 | 29.6 | The starting dose is 12.5 mg once daily or twice daily. The total daily dose can be increased in increments of 25 mg to 50 mg per day, if well-tolerated, to achieve a target dose of 300 mg to 450 mg per day (administered in divided doses) by the end of 2 weeks. | 8-Sep-20 |
| Codeine | 90 | 1.1 | 0.0004 | 2.1 | 8.9 | Initiate treatment with codeine sulfate tablets in a dosing range of 15 to 60 mg every 4 hours as needed for pain. | 1-Nov-19 |
| Colchicine | 0.6 | 0.008 | 0.000003 | 0.01 | 0.1 | For prophylaxis of gout flares, the recommended dosage of colchicine capsules is 0.6 mg once or twice daily. | 16-Jun-20 |
| Cortisone | 25 | 0.3 | 0.0001 | 0.6 | 2.5 | The initial dosage varies from 25 to 300 mg a day depending on the disease being treated. The initial dosage should be maintained or adjusted until the patient’s response is satisfactory. | 8-Jun-10 |
| Cromolyn | 800 | 10.0 | 0.003 | 18.6 | 78.9 | For adults and adolescents (13 years and older), the dosage is two ampules four times daily, taken one-half hour before meals and at bedtime. Each ampule contains 100 mg/5 mL cromolyn sodium oral solution. | 26-Nov-21 |
| Cyclobenzaprine | 15 | 0.2 | 0.00006 | 0.3 | 1.5 | For most patients, the recommended dose of cyclobenzaprine HCl is 5 mg three times a day. | 30-Dec-19 |
| Cyclophosphamide ҂ | 80 | 1.0 | 0.0003 | 1.9 | 7.9 | Oral cyclophosphamide dosing is usually in the range of 1 to 5 mg/kg-day for both initial and maintenance dosing. (LDD calculated assuming 80 kg adult.) | 6-Nov-06 |
| Cyclosporine | 400 | 5.0 | 0.002 | 9.3 | 39.4 | The initial oral dose of cyclosporine capsules, (non-modified) should be given 4 to 12 hours prior to transplantation as a single dose of 15 mg/kg. The initial single daily dose is continued postoperatively for 1 to 2 weeks and then tapered by 5% per week to a maintenance dose of 5 to 10 mg/kg/day. (LDD calculated assuming 80 kg adult). | 22-Jan-20 |
| Cyproheptadine | 4 | 0.1 | 0.00002 | 0.1 | 0.4 | The therapeutic range is 4 to 20 mg a day, with the majority of patients requiring 12 to 16 mg a day. | 26-Jan-11 |
| Deflazacort | 72 | 0.9 | 0.0003 | 1.7 | 7.1 | The recommended oral dosage of deflazacort is approximately 0.9 mg/kg/day once daily. (LDD calculated assuming 80 kg adult.) | 6-Oct-21 |
| Demeclocycline | 600 | 7.5 | 0.003 | 14.0 | 59.2 | The usual daily dose for adults is four divided doses of 150 mg each or two divided doses of 300 mg each. | 28-Dec-20 |
| Desloratadine | 5 | 0.1 | 0.00002 | 0.1 | 0.5 | The recommended dose of desloratadine tablets is one 5 mg tablet once daily. | 13-Dec-21 |
| Desogestrel | 0.15 | 0.002 | 0.0000006 | 0.003 | 0.01 | Desogestrel is given in combination with ethinyl estradiol. Each orange tablet (debossed with "S3" on one side) contains 0.15 mg desogestrel and 0.03 mg ethinyl estradiol and is taken once per day. To achieve maximum contraceptive effectiveness, desogestrel and ethinyl estradiol tablets must be taken exactly as directed and at intervals not exceeding 24 hours. | 4-Jan-21 |
| Desvenlafaxine | 50 | 0.6 | 0.0002 | 1.2 | 4.9 | The recommended dose for desvenlafaxine is 50 mg once daily, with or without food. The 50 mg dose is both a starting dose and the therapeutic dose. | 9-Oct-19 |
| Dexamethasone | 0.75 | 0.009 | 0.000003 | 0.02 | 0.1 | The initial dosage varies from 0.75 to 9 mg a day depending on the disease being treated. It should be emphasized that dosage requirements are variable and must be individualized on the basis of the disease under treatment and the response of the patient. After a favorable response is noted, the proper maintenance dosage should be determined by decreasing the initial drug dosage in small decrements at appropriate time intervals until the lowest dosage that maintains an adequate clinical response is reached. | 25-Oct-07 |
| Dextroamphetamine | 5 | 0.1 | 0.00002 | 0.1 | 0.5 | Usual dose for narcolepsy is 5 mg to 60 mg per day in divided doses, depending on the individual patient response. | 8-Feb-08 |
| Dextromethorphan | 120 | 1.5 | 0.0005 | 2.8 | 11.8 | Dosage for adults and children 12 years of age and over is 10 mL every 12 hours, not to exceed 20 mL in 24 hours; each 5 mL is equivalent to 30 mg dextromethorphan hydrobromide. | 8-Sep-20 |
| Diazepam | 4 | 0.1 | 0.00002 | 0.1 | 0.4 | Depending upon severity of symptoms, usual daily dose is 2 mg to 10 mg, 2 to 4 times daily. | 9-Mar-21 |
| Diclofenac | 54 | 0.7 | 0.0002 | 1.3 | 5.3 | For management of mild to moderate acute pain, the dosage is 18 mg or 35 mg orally three times daily. | 8-Apr-19 |
| Dicyclomine | 80 | 1.0 | 0.0003 | 1.9 | 7.9 | The recommended initial dose is 20 mg four times a day. After one week treatment with the initial dose, the dose may be increased to 40 mg four times a day unless side effects limit dosage escalation. | 31-May-18 |
| Didanosine | 400 | 5.0 | 0.002 | 9.3 | 39.4 | Recommended dosage for patients at least 60 kg is 400 mg once daily. | 2-May-12 |
| Digoxin ҂ | 0.25 | 0.003 | 0.000001 | 0.006 | 0.025 | Therapy is generally initiated at a dose of 0.25 mg once daily in patients under age 70 with good renal function. | 15-May-19 |
| Dihydrocodeine | 160 | 2.0 | 0.0007 | 3.7 | 15.8 | Dihydrocodeine bitartrate is given in combination with acetaminophen and caffeine in a capsule (as Trezix), with 16 mg dihydrocodeine bitartrate per capsule. The usual adult dosage is 2 Trezix capsules orally every 4 hours, as needed. No more than 5 doses, or 10 capsules should be taken in a 24-hour period. | 1-Feb-20 |
| Diltiazem | 120 | 1.5 | 0.001 | 2.8 | 11.8 | Dosages for the treatment of angina should be adjusted to each patient's needs, starting with a dose of 120 or 180 mg once daily. | 1-Apr-20 |
| Diphenhydramine | 50 | 0.6 | 0.0002 | 1.2 | 4.9 | For adults and children 12 years and over, two 25-mg soft gels at bedtime, if needed or as directed by a doctor. Each soft gel contains 25 mg diphenhydramine HCl. | 9-Dec-19 |
| Diphenoxylate | 4.6 | 0.1 | 0.00002 | 0.1 | 0.5 | Diphenoxylate hydrochloride is given in combination with atropine sulfate in a tablet form as Lomotil. Each Lomotil tablet contains 2.5 mg of diphenoxylate hydrochloride USP (equivalent to 2.3 mg of diphenoxylate) and 0.025 mg of atropine sulfate USP (equivalent to 0.01 mg of atropine). The initial adult dosage is 2 Lomotil tablets four times daily. After initial control has been achieved, the Lomotil dosage may be reduced to meet individual requirements. Control may often be maintained with as little as two Lomotil tablets daily. | 25-Oct-21 |
| Dipyridamole | 300 | 3.8 | 0.001 | 7.0 | 29.6 | The recommended dose is 75 mg to 100 mg four times daily as an adjunct to the usual warfarin therapy. There are no non-adjunct labels. | 15-Dec-21 |
| Disopyramide | 600 | 7.5 | 0.003 | 14.0 | 59.2 | The recommended dosage for most adults is 600 mg/day given in divided doses (150 mg every 6 hours). For patients whose body weight is less than 110 pounds (50 kg), the recommended dosage is 400 mg/day given in divided doses (100 mg every 6 hours). | 31-Aug-15 |
| Disulfiram | 125 | 1.6 | 0.0005 | 2.9 | 12.3 | The average maintenance dose is 250 mg daily (range, 125 to 500 mg), it should not exceed 500 mg daily. | 30-Jan-20 |
| Docusate | 50 | 0.6 | 0.0002 | 1.2 | 4.9 | Dosage for adults and children 12 years and older is 1-6 soft gels (each containing 50 mg docusate sodium), daily | 7-Nov-19 |
| Donepezil | 5 | 0.1 | 0.00002 | 0.1 | 0.5 | The recommended starting dosage of donepezil hydrochloride tablet is 5 mg administered once per day in the evening, just prior to retiring. | 27-Dec-19 |
| Doxazosin | 1 | 0.01 | 0.000004 | 0.02 | 0.1 | The recommended initial dosage of doxazosin tablets is 1 mg given once daily either in the morning or evening. | 30-Nov-21 |
| Doxepin | 3 | 0.04 | 0.00001 | 0.1 | 0.3 | The recommended dose for adults is 6 mg once daily. A 3 mg once daily dose may be appropriate for some patients, if clinically indicated. | 29-Dec-21 |
| Doxycycline | 100 | 1.3 | 0.0004 | 2.3 | 9.9 | Adults: The usual dose of oral doxycycline is 200 mg on the first day of treatment (administered 100 mg every 12 hours) followed by a maintenance dose of 100 mg/day. | 1-Aug-21 |
| Dronabinol | 4.2 | 0.1 | 0.00002 | 0.1 | 0.4 | The recommended adult starting dosage is 2.1 mg orally twice daily, one hour before lunch and one hour before dinner. If tolerated and further therapeutic effect is desired, the dosage may be increased gradually to 2.1 mg one hour before lunch and 4.2 mg one hour before dinner. | 11-Dec-19 |
| Drospirenone | 0.25 | 0.003 | 0.000001 | 0.006 | 0.02 | Drospirenone is given in combination with estradiol as a tablet as Angeliq. Each tablet contains 0.25 mg drospirenone and 0.5 mg estradiol. Dosage is one tablet taken by mouth once daily. | 14-Nov-17 |
| Duloxetine | 40 | 0.5 | 0.0002 | 0.9 | 3.9 | Administer duloxetine delayed-release capsules at a total dose of 40 mg/day (given as 20 mg twice daily) to 60 mg/day (given either once daily or as 30 mg twice daily). | 25-Nov-21 |
| Dutasteride | 0.5 | 0.006 | 0.000002 | 0.01 | 0.05 | The recommended dose of dutasteride capsules is 1 capsule (0.5 mg dutasteride) taken once daily. | 25-Feb-20 |
| Efavirenz | 300 | 3.8 | 0.001 | 7.0 | 29.6 | The recommended dosage of efavirenz is 600 mg orally, once daily, in combination with a protease inhibitor and/or nucleoside analogue reverse transcriptase inhibitors (NRTIs). If efavirenz is coadministered with voriconazole, the efavirenz dose should be decreased to 300 mg once daily. | 22-Nov-21 |
| Enalapril | 5 | 0.1 | 0.00002 | 0.1 | 0.5 | The recommended initial dose in patients not on diuretics is 5 mg once a day. Dosage should be adjusted according to blood pressure response. The usual dosage range is 10 to 40 mg per day administered in a single dose or two divided doses. | 12-May-21 |
| Eprosartan | 400 | 5.0 | 0.0017 | 9.3 | 39.4 | Eprosartan mesylate can be administered once or twice daily with total daily doses ranging from 400 mg to 800 mg. | 3-Jan-12 |
| Erythromycin | 1000 | 12.5 | 0.004 | 23.3 | 98.6 | The usual dose is 250 mg every 6 hours taken one hour before meals. | 19-Mar-19 |
| Escitalopram | 10 | 0.1 | 0.00004 | 0.2 | 1.0 | The recommended dose of escitalopram tablets is 10 mg once daily. | 29-Aug-19 |
| Esomeprazole | 20 | 0.3 | 0.00008 | 0.5 | 2.0 | The recommended dose is 20 mg or 40 mg once daily. | 30-Nov-21 |
| Estradiol ҂ | 1 | 0.01 | 0.000004 | 0.02 | 0.1 | The usual initial dosage range is 1 to 2 mg daily of estradiol adjusted as necessary to control presenting symptoms. The minimal effective dose for maintenance therapy should be determined by titration. | 1-Jan-21 |
| Eszopiclone | 1 | 0.01 | 0.000004 | 0.02 | 0.1 | The recommended starting dose is 1 mg. Dosing can be raised to 2 mg or 3 mg if clinically indicated. | 13-Sep-21 |
| Ethacrynic acid | 50 | 0.6 | 0.0002 | 1.2 | 4.9 | The smallest dose required to produce gradual weight loss (about 1 to 2 pounds per day) is recommended. Onset of diuresis usually occurs at 50 to 100 mg for adults. After diuresis has been achieved, the minimally effective dose (usually from 50 to 200 mg daily) may be given on a continuous or intermittent dosage schedule. | 31-Aug-20 |
| Ethambutol | 1200 | 15.0 | 0.005 | 28.0 | 118.3 | In patients who have not received previous antituberculosus therapy, administer ethambutol hydrochloride at 15 mg/kg (7 mg/lb) of body weight, as a single oral dose once every 24 hours. (LDD calculated assuming 80 kg adult.) | 3-Mar-20 |
| Ethinyl estradiol ҂ | 0.03 | 0.0004 | 0.0000001 | 0.001 | 0.003 | Ethinyl estradiol is given in combination with levonorgestrel. Levonorgestrel and ethinyl estradiol tablets contain 0.15 mg of levonorgestrel and 0.03 mg of ethinyl estradiol. Dosage is one tablet by mouth at the same time every day (0.03 mg/day) | 27-Feb-23 |
| Ethynodiol | 1 | 0.01 | 0.000004 | 0.02 | 0.1 | Ethynodiol diacetate is given in combination with ethinyl estradiol. Each table contains 1 mg ethynodiol diacetate and 50 ug ethinyl estradiol. Take one pill at the same time every day until the pack is empty. | 18-Dec-21 |
| Etidronate disodium | 400 | 5.0 | 0.002 | 9.3 | 39.4 | Dosage is 5 to 10 mg/kg-day for a period not to exceed 3 months. (LDD calculated assuming 80 kg adult.) | 17-Mar-17 |
| Etodolac | 400 | 5.0 | 0.002 | 9.3 | 39.4 | For the relief of the signs and symptoms of osteoarthritis or rheumatoid arthritis, the recommended starting dose of etodolac extended-release tablets is 400 to 1000 mg given orally once per day. | 11-May-21 |
| Etonogestrel | 0.12 | 0.002 | 0.000001 | 0.003 | 0.01 | Etonogestrel is given in combination with ethinyl estradiol (NuvaRing). NuvaRing is a polymeric vaginal ring containing 11.7 mg etonogestrel and 2.7 mg ethinyl estradiol, which releases on average 0.12 mg/day of etonogestrel and 0.015 mg/day of ethinyl estradiol. | 24-Jan-20 |
| Etoposide ҂ | 150 | 1.9 | 0.001 | 3.5 | 14.8 | In small cell lung cancer, the recommended oral dose of etoposide capsules is two times the IV dose rounded to the nearest 50 mg (i.e., two times 35 mg/m2/day for 4 days to 50 mg/m2/day for 5 days). | 19-Apr-16 |
| Everolimus | 1.5 | 0.02 | 0.000006 | 0.03 | 0.1 | An initial everolimus dose of 0.75 mg orally twice daily (1.5 mg per day) is recommended for adult kidney transplant patients in combination with reduced dose cyclosporine, administered as soon as possible after transplantation. | 28-May-21 |
| Exemestane | 25 | 0.3 | 0.0001 | 0.6 | 2.5 | The recommended dose of exemestane in early and advanced breast cancer is one 25 mg tablet once daily. | 14-Dec-21 |
| Ezetimibe | 10 | 0.1 | 0.00004 | 0.2 | 1.0 | The recommended dose of ezetimibe is 10 mg once daily. | 19-Oct-21 |
| Famciclovir | 500 | 6.3 | 0.002 | 11.7 | 49.3 | The recommended dosage of famciclovir for chronic suppressive therapy of recurrent episodes of genital herpes is 250 mg twice daily. | 12-Oct-21 |
| Famotidine | 10 | 0.1 | 0.00004 | 0.2 | 1.0 | To relieve or prevent symptoms, swallow one 10-mg tablet with a glass of water; do not use more than 2 tablets in 24 hours. | 12-Sep-18 |
| Felbamate | 3600 | 45.0 | 0.02 | 83.9 | 355.0 | Increase the dosage of felbamate by 1,200 mg/day increments at weekly intervals to 3,600 mg/day. | 17-Apr-18 |
| Felodipine | 2.5 | 0.03 | 0.00001 | 0.1 | 0.2 | The recommended dosage range is 2.5 mg to 10 mg once daily. | 21-May-21 |
| Fenofibrate | 30 | 0.4 | 0.0001 | 0.7 | 3.0 | The initial dose is 30 to 90 mg per day. Dosage should be individualized according to patient response. | 1-May-21 |
| Fenofibric acid | 35 | 0.4 | 0.0001 | 0.8 | 3.5 | The initial dose is 35 to 105 mg per day. Dosage should be individualized according to patient response. | 10-Oct-18 |
| Fenoprofen | 800 | 10.0 | 0.003 | 18.6 | 78.9 | For the treatment of mild to moderate pain, the recommended dosage is 200 mg given orally every 4 to 6 hours, as needed. | 8-Jun-16 |
| Fentanyl | 0.1 | 0.001 | 0.0000004 | 0.002 | 0.01 | Initiate treatment with fentanyl for all patients with a single initial dose of 100 ug. If adequate analgesia is obtained within 30 minutes of administration of the 100 ug tablet, continue to treat subsequent episodes of breakthrough pain with this dose. | 16-Dec-19 |
| Fexofenadine | 120 | 1.5 | 0.0005 | 2.8 | 11.8 | The recommended dose of fexofenadine hydrochloride tablets is 60 mg twice daily or 180 mg once daily with water. | 11-Nov-21 |
| Finasteride | 1 | 0.01 | 0.000004 | 0.02 | 0.1 | The recommended dose is one tablet (1 mg finasteride) taken once daily. | 13-Oct-21 |
| Fluconazole | 50 | 0.6 | 0.0002 | 1.2 | 4.9 | For the treatment of Candida urinary tract infections and peritonitis, daily doses of 50 to 200 mg have been used in open, noncomparative studies of small numbers of patients. | 14-Jan-19 |
| Fludrocortisone acetate | 0.043 | 0.0005 | 0.0000002 | 0.001 | 0.004 | The usual dose is 0.1 mg of fludrocortisone acetate tablets daily, although dosage ranging from 0.1 mg three times a week to 0.2 mg daily has been employed. In the event transient hypertension develops as a consequence of therapy, the dose should be reduced to 0.05 mg daily. | 18-May-21 |
| Fluoxetine | 20 | 0.3 | 0.00008 | 0.5 | 2.0 | 20 mg/day is sufficient to obtain a satisfactory response in Major Depressive Disorder in most cases; consequently, a dose of 20 mg/day, administered in the morning, is recommended as the initial dose. | 18-Nov-10 |
| Fluoxymesterone | 2.5 | 0.03 | 0.00001 | 0.1 | 0.2 | Dosage is within the range of 2.5 to 20 mg daily, although generally in the lower range of 2.5 to 10 mg daily, and for a limited duration, for example 4 to 6 months. | 21-Sep-17 |
| Fluphenazine | 1 | 0.01 | 0.000004 | 0.02 | 0.1 | When symptoms are controlled, dosage can generally be reduced gradually to daily maintenance doses of 1 to 5 mg, often given as a single daily dose. | 11-Jan-22 |
| Flurazepam | 15 | 0.2 | 0.00006 | 0.3 | 1.5 | Use the lowest dose effective for the patient, as important adverse effects of flurazepam hydrochloride capsules are dose related. The recommended initial dose is 15 mg for women and either 15 mg or 30 mg for men. The 15 mg dose can be increased to 30 mg if necessary for efficacy. | 24-Feb-21 |
| Flutamide | 750 | 9.4 | 0.003 | 17.5 | 74.0 | The recommended dosage is two 125-mg capsules three times a day at 8-hour intervals for a total daily dose of 750 mg. | 29-Nov-18 |
| Fluvastatin | 20 | 0.3 | 0.00008 | 0.5 | 2.0 | The dose range is 20 mg/day to 80 mg/day. | 13-Jun-21 |
| Fluvoxamine | 50 | 0.6 | 0.0002 | 1.2 | 4.9 | The recommended starting dose for adult patients is 50 mg, administered as a single daily dose at bedtime. In the controlled clinical trials establishing the effectiveness of fluvoxamine maleate tablets in OCD, patients were titrated within a dose range of 100 to 300 mg/day. Consequently, the dose should be increased in 50 mg increments every 4 to 7 days, as tolerated, until maximum therapeutic benefit is achieved, not to exceed 300 mg per day. | 30-Nov-21 |
| Fosfomycin | 3000 | 37.5 | 0.01 | 69.9 | 295.9 | The recommended dosage for women 18 years of age and older for uncomplicated urinary tract infection (acute cystitis) is one sachet (3 g of fosfomycin). | 24-Oct-19 |
| Furosemide | 20 | 0.3 | 0.0001 | 0.5 | 2.0 | The usual initial dose of furosemide is 20 to 80 mg given as a single dose. | 26-Aug-20 |
| Gabapentin | 900 | 11.3 | 0.004 | 21.0 | 88.8 | The effective dose of gabapentin capsules is 900 to 1800 mg/day and given in divided doses (three times a day) using 300 or 400 mg capsules. | 3-Mar-14 |
| Gemfibrozil ҂ | 1200 | 15.0 | 0.005 | 28.0 | 118.3 | The recommended dose for adults is 1200 mg administered in two divided doses 30 minutes before the morning and evening meal. | 1-Jan-07 |
| Glipizide | 5 | 0.1 | 0.00002 | 0.1 | 0.5 | The recommended starting dose is 5 mg, given before breakfast. There is no fixed dosage regimen for the management of diabetes mellitus with glipizide or any other hypoglycemic agent. | 8-Nov-19 |
| Glyburide | 1.25 | 0.02 | 0.000005 | 0.03 | 0.1 | The usual maintenance dose is in the range of 1.25 to 20 mg daily, which may be given as a single dose or in divided doses. | 27-Dec-19 |
| Griseofulvin ҂ | 375 | 4.7 | 0.002 | 8.7 | 37.0 | Daily administration of 375 mg (as a single dose or in divided doses) will give a satisfactory response in most patients with tinea corporis, tinea cruris, and tinea capitis. | 27-May-16 |
| Guaifenesin | 1200 | 15.0 | 0.005 | 28.0 | 118.3 | Dosage for adults and children 12 years of age and over is two to four (100 mg guaifenesin) tablets every 4 hours. | 15-Oct-18 |
| Guanfacine | 1 | 0.01 | 0.000004 | 0.02 | 0.1 | The recommended initial dose of guanfacine hydrochloride when given alone or in combination with another antihypertensive drug is 1 mg daily given at bedtime to minimize somnolence. | 31-Jul-14 |
| Haloperidol | 1 | 0.01 | 0.000004 | 0.02 | 0.1 | In adults with moderate symptomatology, the initial dosage range is 0.5 mg to 2 mg b.i.d. or t.i.d. Upon achieving a satisfactory therapeutic response, dosage should then be gradually reduced to the lowest effective maintenance level. | 8-Jun-20 |
| Hydralazine | 40 | 0.5 | 0.0002 | 0.9 | 3.9 | Initiate therapy in gradually increasing dosages; adjust according to individual response. Start with 10 mg four times daily for the first 2 to 4 days, increase to 25 mg four times daily for the balance of the first week. For the second and subsequent weeks, increase dosage to 50 mg four times daily. For maintenance, adjust dosage to the lowest effective levels. | 28-Dec-17 |
| Hydrochlorothiazide ҂ | 12.5 | 0.2 | 0.00005 | 0.3 | 1.2 | The adult initial dose of hydrochlorothiazide is one 12.5-mg capsule given once daily whether given alone or in combination with other anti-hypertensives. Total daily doses greater than 50 mg are not recommended. | 5-Nov-21 |
| Hydrocodone | 20 | 0.3 | 0.00008 | 0.5 | 2.0 | Initiate treatment with hydrocodone bitartrate with one 10 mg capsule every 12 hours. | 25-Feb-15 |
| Hydrocortisone | 20 | 0.3 | 0.0001 | 0.5 | 2.0 | The initial dosage of hydrocortisone tablets may vary from 20 mg to 240 mg of hydrocortisone per day. The initial dosage should be maintained or adjusted until a satisfactory response is noted. | 19-Aug-21 |
| Hydromorphone | 8 | 0.1 | 0.00003 | 0.2 | 0.8 | The usual starting dose for hydromorphone hydrochloride tablets is 2 mg to 4 mg, orally, every 4 to 6 hours. | 10-Jan-07 |
| Hydroxychloroquine | 57.1 | 0.7 | 0.0002 | 1.3 | 5.6 | The recommended dosage is 200 mg given once daily, or 400 mg given once daily or in two divided doses. For prophylaxis, the recommended dosage is 400 mg once a week. | 30-Sep-21 |
| Hydroxyzine | 50 | 0.6 | 0.0002 | 1.2 | 4.9 | For use in the management of pruritus due to allergic conditions such as chronic urticaria and atopic and contact dermatoses, and in histamine-mediated pruritus the dosage in adults is 25 mg t.i.d. or q.i.d. The dosage for use as a sedative when used as a premedication and following general anesthesia is 50–100 mg in adults. | 20-Jun-06 |
| Ibuprofen | 800 | 10.0 | 0.003 | 18.6 | 78.9 | Take one 200-mg tablet every 4 to 6 hours while symptoms persist. | 11-Nov-21 |
| Imipramine | 50 | 0.6 | 0.0002 | 1.2 | 4.9 | For outpatients, the dosage initially is 75 mg/day increased to 150 mg/day. Dosages over 200 mg/day are not recommended. For maintenance, the dosage is 50 to 150 mg/day. | 2-Feb-22 |
| Indomethacin | 50 | 0.6 | 0.0002 | 1.2 | 4.9 | Dosage is 25 mg twice a day or three times a day for moderate to severe rheumatoid arthritis. If this is well tolerated, increase the daily dosage by 25 mg or by 50 mg, if required | 28-Oct-21 |
| Irbesartan | 150 | 1.9 | 0.0006 | 3.5 | 14.8 | The recommended initial dose of irbesartan tablets is 150 mg once daily. The dosage can be increased to a maximum dose of 300 mg once daily as needed to control blood pressure. | 1-Oct-21 |
| Isoniazid | 300 | 3.8 | 0.001 | 7.0 | 29.6 | 5 mg/kg up to 300 mg daily in a single dose; or 15 mg/kg up to 900 mg/day, two or three times/week. (LDD calculated assuming 80 kg adult.) | 26-Mar-18 |
| Isosorbide dinitrate | 20 | 0.3 | 0.00008 | 0.5 | 2.0 | The usual starting dose of isosorbide dinitrate is 5 mg to 20 mg, two or three times daily. For maintenance therapy, 10 mg to 40 mg, two or three times daily is recommended. | 20-Aug-21 |
| Isosorbide mononitrate | 40 | 0.5 | 0.0002 | 0.9 | 3.9 | The recommended regimen of isosorbide mononitrate tablets is 20 mg twice daily, with the doses seven hours apart. | 31-Jan-15 |
| Itraconazole | 200 | 2.5 | 0.001 | 4.7 | 19.7 | The recommended dose is 200 mg once daily (2 capsules). | 14-Oct-19 |
| Ketoconazole | 200 | 2.5 | 0.0008 | 4.7 | 19.7 | The recommended starting dose of ketoconazole tablets is a single daily administration of 200 mg (one tablet). If clinical responsiveness is insufficient within the expected time, the dose of ketoconazole tablets may be increased to 400 mg (two tablets) once daily. | 1-Nov-21 |
| Ketoprofen | 75 | 0.9 | 0.0003 | 1.7 | 7.4 | The usual dose of ketoprofen immediate-release capsules recommended for mild to moderate pain and dysmenorrhea is 25 to 50 mg every 6 to 8 hours as necessary. | 12-Jan-22 |
| Labetalol | 400 | 5.0 | 0.002 | 9.3 | 39.4 | The recommended initial dosage is 100 mg twice daily whether used alone or added to a diuretic regimen. After 2 or 3 days, using standing blood pressure as an indicator, dosage may be titrated in increments of 100 mg b.i.d. every 2 or 3 days. The usual maintenance dosage of labetalol HCl is between 200 and 400 mg twice daily. | 14-Nov-19 |
| Lamivudine | 100 | 1.3 | 0.0004 | 2.3 | 9.9 | The recommended oral dosage of lamivudine tablets is 100 mg once daily. | 26-Mar-21 |
| Lamotrigine | 200 | 2.5 | 0.0008 | 4.7 | 19.7 | The maintenance range (week 8 and onward) is 200 to 250 mg every day in patients taking lamotrigine for adjunctive therapy for primary generalized tonic-clonic and partial-onset seizures. For conversion to monotherapy, the target therapeutic dosage range is 250 to 300 mg daily. | 27-Dec-20 |
| Lansoprazole | 15 | 0.2 | 0.00006 | 0.3 | 1.5 | The recommended dose for treating frequent heartburn is 15 mg daily for 14 days. | 13-Aug-21 |
| Letrozole | 2.5 | 0.03 | 0.00001 | 0.1 | 0.2 | The recommended dose of letrozole tablets is one 2.5 mg tablet administered once a day, without regard to meals. | 26-Aug-20 |
| Levetiracetam | 1000 | 12.5 | 0.004 | 23.3 | 98.6 | Treatment should be initiated with a daily dose of 1000 mg/day. The once daily dosage may be adjusted in increments of 1000 mg every 2 weeks to a maximum recommended daily dose of 3000 mg/day once daily. | 6-Oct-21 |
| Levodopa | 300 | 3.8 | 0.001 | 7.0 | 29.6 | Per label, levodopa is given in combination with carbidopa as SINEMET. Dosage is best initiated with one tablet of SINEMET 25-100 three times a day. Dosage may be increased by one tablet every day or every other day, as necessary, until a dosage of eight tablets of SINEMET 25-100 a day is reached. For maintenance, at least 70 to 100 mg of carbidopa per day should be provided. Sinemet 25-100 contains 25 mg of carbidopa and 100 mg of levodopa. (Levodopa only drug products are discontinued according to Drugs@FDA). | 15-Oct-21 |
| Levofloxacin | 250 | 3.1 | 0.001 | 5.8 | 24.7 | The usual dose of levofloxacin tablets is 250 mg, 500 mg, or 750 mg administered orally every 24 hours, as indicated by infection. | 6-Dec-17 |
| Levonorgestrel | 1.5 | 0.02 | 0.000006 | 0.03 | 0.1 | The usual dose of Levonorgestrel is one tablet. Each tablet has 1.5 mg of Levonorgestre. | 2-Feb-23 |
| Levorphanol | 3 | 0.04 | 0.00001 | 0.1 | 0.3 | Initiate treatment with levorphanol tartrate tablets in a dosing range of 1 to 2 mg every 6 to 8 hours as needed for pain. If necessary, the dose may be increased to up to 3 mg every 6 to 8 hours, after adequate evaluation of the patient's response. | 8-Jan-21 |
| Levothyroxine | 0.128 | 0.002 | 0.0000005 | 0.003 | 0.01 | The average full replacement dose of levothyroxine sodium is approximately 1.6 ug/kg-day (e.g., 100-125 ug/day for a 70 kg adult). (LDD calculated assuming 80 kg adult.) | 11-Feb-22 |
| Lidocaine | 300 | 3.8 | 0.001 | 7.0 | 29.6 | The maximum recommended single dose of lidocaine HCl should not exceed 4.5 mg/kg or 2 mg/lb body weight and does not in any case exceed a total of 300 mg. | 27-Aug-21 |
| Liothyronine | 0.025 | 0.0003 | 0.0000001 | 0.0006 | 0.002 | Usual maintenance dose is 25 ug to 75 ug daily. | 30-Jan-21 |
| Lisdexamfetamine | 30 | 0.4 | 0.0001 | 0.7 | 3.0 | The recommended starting dose is 30 mg once daily in the morning in patients ages 6 and above. Dosage may be adjusted in increments of 10 mg or 20 mg at approximately weekly intervals up to maximum dose of 70 mg/day. | 10-Nov-21 |
| Lisinopril | 5 | 0.1 | 0.00002 | 0.1 | 0.5 | The usual effective dosage range for heart failure is 5 to 20 mg per day administered as a single daily dose. | 2-Mar-07 |
| Lomefloxacin | 400 | 5.0 | 0.002 | 9.3 | 39.4 | The recommended daily dose of lomefloxacin hydrochloride is 400 mg. | 11-May-06 |
| Loperamide | 4 | 0.1 | 0.00002 | 0.1 | 0.4 | For adults and children 12 years of age and over, the dosage is 2 soft gels (2 mg loperamide HCl/soft gel) after the first loose stool, and 1 soft gel after each subsequent loose stool, but no more than 4 soft gels in 24 hours. | 20-Oct-21 |
| Loratadine | 10 | 0.1 | 0.00004 | 0.2 | 1.0 | For adults and children 6 years and older, the dosage is one 5-mg tablet every 12 hours, with not more than 2 tablets in 24 hours. | 26-Jan-22 |
| Lorazepam | 1 | 0.01 | 0.000004 | 0.02 | 0.1 | The usual range is 2 to 6 mg/day given in divided doses, with the largest dose being taken before bedtime. The daily dosage may vary from 1 to 10 mg/day. | 2-Feb-21 |
| Losartan | 50 | 0.6 | 0.0002 | 1.2 | 4.9 | The usual starting dose of losartan potassium tablets is 50 mg once daily. The dosage can be increased to a maximum dose of 100 mg once daily as needed to control blood pressure. | 15-Sep-21 |
| Lovastatin | 10 | 0.1 | 0.00004 | 0.2 | 1.0 | The recommended dosing range of lovastatin is 10 to 80 mg/day in single or two divided doses. | 6-Jan-21 |
| Loxapine | 20 | 0.3 | 0.00008 | 0.5 | 2.0 | Many patients have been maintained satisfactorily at dosages in the range of 20 to 60 mg daily, although the usual therapeutic and maintenance range is 60 mg to 100 mg daily. | 9-Feb-16 |
| Lumefantrine | 960 | 12.0 | 0.004 | 22.4 | 94.7 | Lumefantrine is given in combination with artemether as COARTEM tablets. COARTEM tablets should be administered over 3 days for a total of 6 doses: an initial dose, second dose after 8 hours, and then twice-daily (morning and evening) for the following 2 days. The adult dosage for patients with bodyweight of 35 kg and above is 4 COARTEM tablets per dose for a total of 6 doses over 3 days. COARTEM tablets are scored and contain 20 mg artemether and 120 mg lumefantrine. | 7-Jun-22 |
| Maprotiline | 75 | 0.9 | 0.0003 | 1.7 | 7.4 | Dosage during prolonged maintenance therapy should be kept at the lowest effective level. Dosage may be reduced to levels of 75 mg to 150 mg daily during such periods, with subsequent adjustment depending on therapeutic response. | 26-Jun-21 |
| Meclizine | 25 | 0.3 | 0.0001 | 0.6 | 2.5 | The recommended dosage is 25 mg to 100 mg daily administered orally, in divided doses, depending upon clinical response. | 30-Dec-20 |
| Meclofenamate | 200 | 2.5 | 0.0008 | 4.7 | 19.7 | The recommended dose is 50 mg every 4 to 6 hours. | 15-May-21 |
| Medroxyprogesterone | 5 | 0.1 | 0.00002 | 0.1 | 0.5 | Medroxyprogesterone acetate tablets may be given in dosages of 5 or 10 mg daily for 5 to 10 days | 31-May-15 |
| Mefenamic acid | 1000 | 12.5 | 0.004 | 23.3 | 98.6 | For the relief of acute pain in adults and adolescents ≥ 14 years of age, the recommended dose is 500 mg as an initial dose followed by 250 mg every 6 hours as needed, usually not to exceed one week. | 29-Nov-21 |
| Mefloquine | 35.7 | 0.4 | 0.0001 | 0.8 | 3.5 | For malaria prophylaxis in adults, the dosage is one 250 mg mefloquine hydrochloride tablet once weekly. | 31-May-16 |
| Megestrol acetate ҂ | 40 | 0.5 | 0.0002 | 0.9 | 3.9 | For treatment of endometrial carcinoma, the dosage is 40 to 320 mg/day in divided doses. | 4-Oct-18 |
| Meloxicam | 5 | 0.1 | 0.00002 | 0.1 | 0.5 | For management of osteoarthritis pain, the recommended starting dosage is 5 mg orally once daily. Dose may be increased to 10 mg in patients who require additional analgesia. | 8-Apr-19 |
| Melphalan ҂ | 2 | 0.03 | 0.000008 | 0.05 | 0.2 | When the white blood cell and platelet counts are rising, a maintenance dose of 2 mg daily may be instituted. | 30-Nov-21 |
| Memantine | 20 | 0.3 | 0.0001 | 0.5 | 2.0 | The recommended starting dose of memantine hydrochloride is 5 mg once daily. The dose should be increased in 5 mg increments to 10 mg/day (5 mg twice daily), 15 mg/day (5 mg and 10 mg as separate doses), and 20 mg/day (10 mg twice daily). The minimum recommended interval between dose increases is one week. The dosage shown to be effective in controlled clinical trials is 20 mg/day. | 11-Oct-21 |
| Meperidine | 300 | 3.8 | 0.001 | 7.0 | 29.6 | The usual dosage is 50 mg to 150 mg orally, every 3 or 4 hours as necessary. | 30-Mar-07 |
| Meprobamate | 1200 | 15.0 | 0.005 | 28.0 | 118.3 | The usual adult daily dosage is 1200 mg to 1600 mg, in three or four divided doses. A daily dosage above 2400 mg is not recommended. | 1-Oct-21 |
| Mesalamine | 1500 | 18.8 | 0.006 | 35.0 | 147.9 | The recommended dose for maintenance of remission of ulcerative colitis in adult patients is 1.5 g orally once daily in the morning (based on four 0.375 g capsules). | 4-Nov-21 |
| Metaxalone | 2400 | 30.0 | 0.01 | 55.9 | 236.7 | The recommended dose for adults and children over 12 years of age is one 800 mg tablet three to four times a day. | 11-May-20 |
| Metformin | 1500 | 18.8 | 0.006 | 35.0 | 147.9 | In general, clinically significant responses are not seen at doses below 1500 mg per day. | 7-Feb-17 |
| Methadone | 20 | 0.3 | 0.00008 | 0.5 | 2.0 | Initially, a single dose of 20 to 30 mg of methadone will often be sufficient to suppress withdrawal symptoms. | 8-May-08 |
| Methamphetamine hydrochloride | 5 | 0.1 | 0.00002 | 0.1 | 0.5 | An initial dose of 5 mg methamphetamine hydrochloride tablets once or twice a day is recommended. Daily dosage may be raised in increments of 5 mg at weekly intervals until an optimum clinical response is achieved. The usual effective dose is 20 to 25 mg daily. | 15-Aug-19 |
| Methimazole | 5 | 0.1 | 0.00002 | 0.1 | 0.5 | The initial daily dosage is 15 mg for mild hyperthyroidism, 30 to 40 mg for moderately severe hyperthyroidism, and 60 mg for severe hyperthyroidism, divided into 3 doses at 8-hour intervals. The maintenance dosage is 5 to 15 mg daily. | 4-Aug-07 |
| Methocarbamol | 4000 | 50.0 | 0.02 | 93.2 | 394.5 | Six grams a day are recommended for the first 48 to 72 hours of treatment. Thereafter, the dosage can usually be reduced to approximately 4 grams a day. | 2-Jul-20 |
| Methotrexate | 0.714 | 0 | 0.000003 | 0.02 | 0.1 | For relapsed or refractory non-Hodgkin lymphoma, the recommended dosage is 2.5 mg orally two to four times per week as part of metronomic combination chemotherapy. | 23-Dec-21 |
| Methyldopa | 500 | 6.3 | 0.002 | 11.7 | 49.3 | The usual daily dosage of methyldopa tablets is 500 mg to 2 g in two to four doses. | 6-Feb-21 |
| Methylphenidate | 10 | 0.1 | 0.00004 | 0.2 | 1.0 | The recommended starting dose of methylphenidate hydrochloride extended-release capsules is 20 mg once daily. Dosage may be adjusted in weekly 10 mg increments to a maximum of 60 mg/day taken once daily. When a lower initial dose is appropriate, patients may begin treatment with 10 mg. | 16-Jun-21 |
| Methylprednisolone | 4 | 0.1 | 0.00002 | 0.1 | 0.4 | The initial dosage of methylprednisolone tablets may vary from 4 mg to 48 mg of methylprednisolone per day depending on the specific disease entity being treated. The initial dosage should be maintained or adjusted until a satisfactory response is noted. | 15-Aug-18 |
| Methyltestosterone | 10 | 0.1 | 0.00004 | 0.2 | 1.0 | Replacement therapy in androgen-deficient males is 10 to 50 mg of methyltestosterone daily. | 27-May-19 |
| Metoclopramide | 40 | 0.5 | 0.0002 | 0.9 | 3.9 | The recommended dosage is 10 mg dose four times daily at least 30 minutes before eating and at bedtime for 2 to 8 weeks. | 2-Dec-20 |
| Metoprolol | 25 | 0.3 | 0.0001 | 0.6 | 2.5 | The usual initial dosage is 25 to 100 mg daily in a single dose, whether used alone or added to a diuretic. | 1-Nov-09 |
| Metronidazole ҂ | 750 | 9.4 | 0.003 | 17.5 | 74.0 | For trichomoniasis, the dosage for a seven-day course of treatment is 250 mg three times daily for seven consecutive days. | 5-Jan-22 |
| Miconazole | 50 | 0.6 | 0.0002 | 1.2 | 4.9 | The recommended dosing schedule for miconazole is the application of one 50 mg buccal tablet to the upper gum region (canine fossa) once daily for 14 consecutive days. | 1-Jan-22 |
| Minocycline | 200 | 2.5 | 0.0008 | 4.7 | 19.7 | The usual dosage of minocycline hydrochloride capsules is 200 mg initially followed by 100 mg every 12 hours. | 12-Sep-18 |
| Mirtazapine | 15 | 0.2 | 0.0001 | 0.3 | 1.5 | The recommended starting dose of mirtazapine tablets is 15 mg once daily, administered orally, preferably in the evening prior to sleep. If patients do not have an adequate response to the initial 15 mg dose, increase the dose up to a maximum of 45 mg per day. | 30-May-21 |
| Misoprostol | 0.4 | 0.005 | 0.0000017 | 0.009 | 0.04 | The recommended adult oral dose of misoprostol for reducing the risk of NSAID-induced gastric ulcers is 200 ug four times daily with food. If this dose cannot be tolerated, a dose of 100 ug can be used. | 4-Jun-19 |
| Mitotane | 2000 | 25.0 | 0.008 | 46.6 | 197.2 | The recommended initial dose of mitotane is 2 g to 6 g orally, in three or four divided doses per day. Increase doses incrementally to achieve a blood concentration of 14 to 20 mg/L, or as tolerated. | 25-Jun-21 |
| Modafinil | 200 | 2.5 | 0.0008 | 4.7 | 19.7 | The recommended dosage of modafinil for patients with narcolepsy or obstructive sleep apnea (OSA) is 200 mg taken orally once a day as a single dose in the morning. | 1-Oct-21 |
| Montelukast | 10 | 0.1 | 0.00004 | 0.2 | 1.0 | One 10 mg tablet is the recommended dose for adults and adolescents 15 years of age and older. | 22-Dec-21 |
| Morphine | 30 | 0.4 | 0.0001 | 0.7 | 3.0 | Dosage is highly individualized. The starting dose of morphine sulfate for patients who are not opioid tolerant is 30 mg orally every 24 hours. | 31-Aug-21 |
| Moxidectin | 8 | 0.1 | 0.00003 | 0.2 | 0.8 | The recommended dosage of moxidectin is a single dose of 8 mg (four 2 mg tablets) taken orally with or without food. | 14-Jan-22 |
| Moxifloxacin hydrochloride | 400 | 5.0 | 0.002 | 9.3 | 39.4 | The dose of moxifloxacin hydrochloride is 400 mg (orally) once every 24 hours. The duration of therapy depends on the type of infection. | 5-Feb-21 |
| Mycophenolate mofetil | 2000 | 25.0 | 0.008 | 46.6 | 197.2 | A dose of 1 g administered orally twice a day (daily dose of 2 g) is recommended for use in renal transplant patients. | 17-Nov-21 |
| Mycophenolic acid | 1440 | 18.0 | 0.006 | 33.6 | 142.0 | The recommended dose of mycophenolic acid is 720 mg administered twice daily (1440 mg total daily dose). | 11-Nov-20 |
| Nabumetone | 1000 | 12.5 | 0.004 | 23.3 | 98.6 | The recommended starting dose is 1000 mg taken as a single dose with or without food. Some patients may obtain more symptomatic relief from 1500 mg to 2000 mg per day. | 27-Feb-19 |
| Nadolol | 40 | 0.5 | 0.0002 | 0.9 | 3.9 | The usual maintenance dose is 40 or 80 mg administered once daily. | 14-Jul-21 |
| Naloxone | 1 | 0.01 | 0.000004 | 0.02 | 0.1 | Naloxone is given in combination with buprenorphine as a tablet. The maintenance dose of buprenorphine and naloxone sublingual tablets are generally in the range of 4 mg/1 mg buprenorphine/naloxone to 24 mg/6 mg buprenorphine/naloxone per day depending on the individual patient. The recommended target dosage of buprenorphine and naloxone sublingual tablets are 16 mg/4 mg buprenorphine/naloxone/day as a single daily dose. | 31-Jan-22 |
| Naltrexone | 50 | 0.6 | 0.0002 | 1.2 | 4.9 | A dose of 50 mg naltrexone hydrochloride once daily is recommended for most patients. | 8-Feb-17 |
| Naproxen | 400 | 5.0 | 0.002 | 9.3 | 39.4 | For adults and children 12 years and older, the dosage is one 200-mg tablet every 8 to 12 hours while symptoms last. | 20-Jul-21 |
| Nebivolol | 5 | 0.1 | 0.00002 | 0.1 | 0.5 | For most patients, the recommended starting dose is 5 mg once daily. For patients requiring further reduction in blood pressure, the dose can be increased at 2-week intervals up to 40 mg. | 16-Dec-21 |
| Nefazodone | 300 | 3.8 | 0.001 | 7.0 | 29.6 | The recommended starting dose for nefazodone hydrochloride is 200 mg/day, administered in two divided doses (b.i.d.). In the controlled clinical trials establishing the antidepressant efficacy of nefazodone, the effective dose range was generally 300 to 600 mg/day. | 24-Dec-08 |
| Neomycin | 4000 | 50.0 | 0.02 | 93.2 | 394.5 | The recommended dose is 4 to 12 grams per day. | 2-Mar-20 |
| Nevirapine | 200 | 2.5 | 0.0008 | 4.7 | 19.7 | Patients must initiate therapy with one 200 mg tablet of immediate-release nevirapine daily for the first 14 days in combination with other antiretroviral agents. The 14-day lead-in period with nevirapine tablets 200 mg daily dosing must be strictly followed (the lead-in period has been observed to decrease the incidence of rash), followed by one 400 mg tablet of nevirapine extended-release once daily. | 22-Oct-21 |
| Nicotine | 6 | 0.1 | 0.00003 | 0.1 | 0.6 | - For weeks 1-6, the dosage is one 2-mg lozenge every 1 to 2 hours (12 x 2 mg = 24 mg/day) - For weeks 7-8, the dosage is one 2-mg lozenge every 2 to 4 hours (6 x 2 mg = 12 mg/day) - For weeks 10-12, the dosage is one 2-mg lozenge every 4 to 8 hours (3 x 2 mg = 6 mg/day) | 28-Jan-20 |
| Nifedipine | 30 | 0.4 | 0.0001 | 0.7 | 3.0 | Therapy for either hypertension or angina should be initiated with 30 or 60 mg once daily. Titration to doses above 120 mg are not recommended. | 2-Dec-20 |
| Nilutamide | 150 | 1.9 | 0.0006 | 3.5 | 14.8 | The recommended dosage is 300 mg once a day for 30 days, followed thereafter by 150 mg once a day. | 18-Sep-20 |
| Nimodipine | 360 | 4.5 | 0.002 | 8.4 | 35.5 | The recommended oral dose is 60 mg (two 30 mg capsules) every 4 hours for 21 consecutive days. | 3-Dec-21 |
| Nitrofurantoin | 200 | 2.5 | 0.0008 | 4.7 | 19.7 | For adults and pediatric patients over 12 years, the dosage is one 100 mg capsule every 12 hours for seven days. | 23-Mar-09 |
| Nizatidine | 150 | 1.9 | 0.0006 | 3.5 | 14.8 | The recommended oral dosage for adults is 150 mg once daily at bedtime. | 31-Mar-16 |
| Norethindrone | 0.35 | 0.004 | 0.000001 | 0.008 | 0.03 | One 0.35-mg tablet is taken every day, at the same time. | 6-Dec-18 |
| Norgestimate | 0.09 | 0.001 | 0.0000004 | 0.002 | 0.009 | Norgestimate is given in combination with estradiol as a tablet (Prefest). The Prefest regimen consists of the daily administration of a single tablet containing 1 mg estradiol (peach color) for three days followed by a single tablet of 1 mg estradiol combined with 0.09 mg norgestimate (white color) for three days. | 29-Feb-16 |
| Norgestrel | 0.3 | 0.004 | 0.000001 | 0.007 | 0.03 | Norgestrel is given in combination with ethinyl estradiol as a tablet (Low-Ogestrel). To achieve maximum contraceptive effectiveness, Low-Ogestrel (0.3 mg norgestrel and 0.03 mg ethinyl estradiol) must be taken exactly as directed and at intervals not exceeding 24 hours. The dosage of Low-Ogestrel is one white tablet daily for 21 consecutive days, followed by one peach inert tablet daily for 7 consecutive days, according to prescribed schedule. | 1-Jul-21 |
| Nortriptyline | 75 | 0.9 | 0.0003 | 1.7 | 7.4 | The usual adult dose is 25 mg three or four times daily. The dosage should begin at a low level and be increased as required. As an alternate regimen, the total daily dosage may be given once a day. | 24-Mar-21 |
| Nystatin | 342 | 4.3 | 0.001 | 8.0 | 33.7 | The usual therapeutic dosage is one to two tablets (500,000 to 1,000,000 units nystatin) three times daily. Treatment should generally be continued for at least 48 hours after clinical cure to prevent relapse. Per FDA feedback, 500k units nystatin = 114 mg. | 12-Apr-22 |
| Ofloxacin | 400 | 5.0 | 0.002 | 9.3 | 39.4 | The usual dose of ofloxacin tablets is 200 mg to 400 mg orally every 12 hours. | 5-Dec-18 |
| Olanzapine | 10 | 0.1 | 0.00004 | 0.2 | 1.0 | Dose Selection - Oral olanzapine should be administered on a once-a-day schedule without regard to meals, generally beginning with 5 to 10 mg initially, with a target dose of 10 mg/day within several days. | 23-Oct-15 |
| Olmesartan medoxomil | 20 | 0.3 | 0.00008 | 0.5 | 2.0 | Dosage must be individualized. The usual recommended starting dose of olmesartan medoxomil is 20 mg once daily when used as monotherapy in patients who are not volume-contracted. | 23-Nov-21 |
| Omeprazole | 20 | 0.3 | 0.00008 | 0.5 | 2.0 | Swallow 1 tablet (20 mg omeprazole) with a glass of water before eating in the morning; take every day for 14 days. | 11-Jun-19 |
| Ondansetron | 16 | 0.2 | 0.00007 | 0.4 | 1.6 | Dosage is 8 mg administered 30 minutes before the start of chemotherapy, with a subsequent 8 mg dose 8 hours after the first dose. Then a dose of 8 mg twice a day (every 12 hours) for 1 to 2 days is administered after completion of chemotherapy. | 5-Jan-22 |
| Orlistat | 180 | 2.3 | 0.001 | 4.2 | 17.8 | For overweight adults 18 years and older, take one 60-mg capsule with each meal containing fat; do not take more than 3 capsules daily. | 9-Nov-20 |
| Orphenadrine | 200 | 2.5 | 0.0008 | 4.7 | 19.7 | For adults, dosage is two 100-mg orphenadrine citrate tablets per day; one in the morning and one in the evening. | 24-Apr-18 |
| Oseltamivir phosphate | 75 | 0.9 | 0.0003 | 1.7 | 7.4 | In adults and adolescents (13 years of age and older), the recommended dosage of oseltamivir phosphate capsules for prophylaxis of influenza is 75 mg orally once daily for at least 10 days following close contact with an infected individual and up to 6 weeks during a community outbreak. | 7-Jan-21 |
| Oxaprozin | 1200 | 15.0 | 0.005 | 28.0 | 118.3 | For osteoarthritis, the dosage is 1200 mg (two 600 mg tablets) given orally once a day. | 26-Oct-21 |
| Oxazepam ҂ | 30 | 0.4 | 0.0001 | 0.7 | 3.0 | For mild-to-moderate anxiety, with associated tension, irritability, agitation or related symptoms of functional origin or secondary to organic disease, the usual dose is 10 to 15 mg, 3 or 4 times daily. | 30-Apr-21 |
| Oxcarbazepine | 1200 | 15.0 | 0.005 | 28.0 | 118.3 | Initiate oxcarbazepine oral suspension with a dose of 600 mg/day, given twice-a-day. If clinically indicated, the dose may be increased by a maximum of 600 mg/day at approximately weekly intervals; the maximum recommended daily dose is 1,200 mg/day. | 28-Dec-20 |
| Oxybutynin | 5 | 0.1 | 0.00002 | 0.1 | 0.5 | The recommended starting dose of oxybutynin chloride extended-release tablets is 5 or 10 mg once daily at approximately the same time each day. Dosage may be adjusted in 5-mg increments to achieve a balance of efficacy and tolerability (up to a maximum of 30 mg/day). | 8-Apr-21 |
| Oxycodone | 20 | 0.3 | 0.00008 | 0.5 | 2.0 | The starting dose for patients who are not opioid tolerant is 10 mg oxycodone HCl extended release tablets orally every 12 hours. | 20-Nov-20 |
| Oxymorphone | 10 | 0.1 | 0.00004 | 0.2 | 1.0 | Initiate treatment with oxymorphone hydrochloride extended-release tablets with the 5 mg tablet orally every 12 hours. | 6-Apr-21 |
| Paliperidone | 3 | 0.04 | 0.00001 | 0.1 | 0.3 | Some patients may benefit from lower or higher doses within the recommended dose range of 3 to 12 mg once daily. | 9-Mar-21 |
| Palonosetron | 0.5 | 0.006 | 0.000002 | 0.012 | 0.05 | Palonosetron is given in combination with netupitant as a capsule (Akynzeo). One Akynzeo capsule containing 300 mg netupitant and 0.5 mg palonosetron is administered approximately 1 hour prior to the start of chemotherapy. | 31-Jan-21 |
| Pantoprazole | 40 | 0.5 | 0.0002 | 0.9 | 3.9 | The dosage is 40 mg once daily for maintenance of healing of erosive esophagitis. | 20-Apr-21 |
| Paroxetine | 7.5 | 0.1 | 0.00003 | 0.2 | 0.7 | The recommended dosage of paroxetine for the treatment of moderate to severe VMS is 7.5 mg once daily, at bedtime, with or without food. | 29-Sep-21 |
| Penicillin V | 250 | 3.1 | 0.001 | 5.8 | 24.7 | For the prevention of recurrence following rheumatic fever and/or chorea due to Fusospirochetosis (Vincent’s infection) of the oropharynx, the dosage is 125 to 250 mg (200,000 to 400,000 units) twice daily on a continuing basis. | 14-Dec-20 |
| Pentoxifylline | 1200 | 15.0 | 0.005 | 28.0 | 118.3 | The usual dosage of pentoxifylline in extended-release tablet form is one tablet (400 mg) three times a day with meals. | 19-Nov-19 |
| Perindopril | 4 | 0.1 | 0.00002 | 0.1 | 0.4 | The usual maintenance dose range is 4 mg to 8 mg administered as a single daily dose or in two divided doses. | 13-Sep-19 |
| Perphenazine | 12 | 0.2 | 0.00005 | 0.3 | 1.2 | Dosage is 4 to 8 mg three times a day initially; reduce as soon as possible to minimum effective dosage. | 31-May-17 |
| Phendimetrazine | 35 | 0.4 | 0.0001 | 0.8 | 3.5 | The usual adult dosage is 1 tablet (35 mg) twice a day or three times a day one hour before meals. The dosage should be individualized to obtain an adequate response with the lowest effective dosage. In some cases, 1/2 tablet (17.5 mg) per dose may be adequate. | 31-Dec-21 |
| Phentermine | 15 | 0.2 | 0.00006 | 0.3 | 1.5 | The usual adult dose is 15 mg to 30 mg as prescribed by the physician, at approximately 2 hours after breakfast for appetite control. | 4-Jan-19 |
| Phenyltoloxamine | 165 | 2.1 | 0.0007 | 3.8 | 16.3 | Phenyltoloxamine citrate is given in combination with acetaminophen in a tablet (ZFLEX). The dosage for adults 12 years and over is one-half or one tablet containing 500 mg acetaminophen and 55 mg phenyltoloxamine citrate every 4 hours. | 12-Apr-10 |
| Phenytoin ҂ | 300 | 3.8 | 0.001 | 7.0 | 29.6 | Adult patients who have received no previous treatment may be started on one 100 mg extended phenytoin sodium capsule three times daily and the dosage then adjusted to suit individual requirements. For most adults, the satisfactory maintenance dosage will be one (100 mg) capsule three to four times a day. | 19-Dec-17 |
| Pioglitazone ҂ | 15 | 0.2 | 0.00006 | 0.3 | 1.5 | The recommended starting dose for patients without congestive heart failure is 15 mg or 30 mg once daily. | 12-Mar-19 |
| Piroxicam | 20 | 0.3 | 0.00008 | 0.5 | 2.0 | For the relief of rheumatoid arthritis and osteoarthritis, the recommended dose is 20 mg given orally once per day. If desired, the daily dose may be divided. | 9-Feb-10 |
| Pramipexole | 0.125 | 0.002 | 0.0000005 | 0.003 | 0.01 | The recommended starting dose of pramipexole dihydrochloride tablets is 0.125 mg taken once daily 2-3 hours before bedtime. For patients requiring additional symptomatic relief, the dose may be increased every 4-7 days. | 29-Dec-10 |
| Pravastatin | 40 | 0.5 | 0.0002 | 0.9 | 3.9 | The recommended starting dose is 40 mg to 80 mg once daily is recommended. | 21-May-21 |
| Prednisolone | 5 | 0.1 | 0.00002 | 0.1 | 0.5 | The initial dosage of prednisolone may vary from 5 mg to 60 mg per day depending on the specific disease entity being treated. In situations of less severity, lower doses will generally suffice, while in selected patients higher initial doses may be required. The initial dosage should be maintained or adjusted until a satisfactory response is noted. | 14-Jul-21 |
| Prednisone | 5 | 0.1 | 0.00002 | 0.1 | 0.5 | The initial dosage may vary from 5 mg to 60 mg of prednisone per day depending on the specific disease entity being treated. | 30-Mar-07 |
| Pregabalin | 150 | 1.9 | 0.0006 | 3.5 | 14.8 | The recommended dose range of pregabalin for the treatment of neuropathic pain associated with spinal cord injury is 150 to 600 mg/day. | 15-Jun-20 |
| Primidone ҂ | 750 | 9.4 | 0.003 | 17.5 | 74.0 | For most adults and children 8 years of age and over, the usual maintenance dosage is three to four 250 mg primidone tablets daily in divided doses (250 mg t.i.d. or q.i.d.). | 1-Oct-21 |
| Prochlorperazine | 15 | 0.2 | 0.00006 | 0.3 | 1.5 | Dosage is usually one 5 mg or 10 mg prochlorperazine maleate tablet 3 or 4 times daily. | 15-Oct-18 |
| Progesterone ҂ | 200 | 2.5 | 0.001 | 4.7 | 19.7 | Progesterone capsules should be given as a single daily dose at bedtime, 200 mg orally for 12 days sequentially per 28-day cycle. | 4-Feb-22 |
| Promethazine | 18.75 | 0.2 | 0.00008 | 0.4 | 1.8 | Single 25 mg doses at bedtime or 6.25 to 12.5 mg taken three times daily will usually suffice. | 29-Dec-20 |
| Propafenone | 450 | 5.6 | 0.002 | 10.5 | 44.4 | Initiate therapy with propafenone hydrochloride tablets 150 mg given every eight hours (450 mg/day). | 28-Feb-19 |
| Propoxyphene | 390 | 4.9 | 0.002 | 9.1 | 38.5 | The usual dosage is one 65 mg propoxyphene hydrochloride capsule every 4 hours as needed for pain. | 27-Oct-09 |
| Propranolol | 30 | 0.4 | 0.0001 | 0.7 | 3.0 | The recommended dose is 10 mg to 30 mg propranolol hydrochloride three or four times daily before meals and at bedtime. | 1-Aug-15 |
| Propylthiouracil ҂ | 100 | 1.3 | 0.00042 | 2.3 | 9.9 | The usual maintenance dose is 100 to 150 mg daily. | 19-Nov-21 |
| Pseudoephedrine | 240 | 3.0 | 0.001 | 5.6 | 23.7 | The recommended dose for adults and children 12 years and over is one 120 mg pseudoephedrine HCl tablet every 12 hours. | 25-Sep-19 |
| Pyrimethamine | 25 | 0.3 | 0.0001 | 0.6 | 2.5 | The adult starting dose is 50 to 75 mg of the drug daily, together with 1 to 4 g daily of a sulfonamide of the sulfapyrimidine type, e.g. sulfadoxine. This dosage is ordinarily continued for 1 to 3 weeks, depending on the response of the patient and tolerance to therapy. The dosage may then be reduced to about one half that previously given for each drug and continued for an additional 4 to 5 weeks. | 11-Nov-21 |
| Quetiapine | 150 | 1.9 | 0.0006 | 3.5 | 14.8 | The recommended dose is 150 to 750 mg/day quetiapine for schizophrenia. | 6-Apr-21 |
| Quinapril | 20 | 0.3 | 0.00008 | 0.5 | 2.0 | The recommended initial dosage of quinapril hydrochloride in patients not on diuretics is 10 or 20 mg once daily. Most patients have required dosages of 20, 40, or 80 mg/day, given as a single dose or in two equally divided doses. | 9-Sep-09 |
| Quinidine | 664 | 8.3 | 0.003 | 15.5 | 65.5 | Therapy with quinidine sulfate should be begun with 200 mg (equivalent to 166 mg of quinidine base) every six hours. If this regimen is well tolerated, if the serum quinidine level is still well within the laboratory’s therapeutic range, and if the average time between arrhythmic episodes has not been satisfactorily increased, then the dose may be cautiously raised. | 13-Sep-19 |
| Quinine | 1944 | 24.3 | 0.008 | 45.3 | 191.7 | For treatment of uncomplicated P. falciparum malaria in adults, the oral dosage of quinine is 648 mg (two capsules) every 8 hours for 7 days. | 29-Dec-20 |
| Rabeprazole | 20 | 0.3 | 0.00008 | 0.5 | 2.0 | The dosage of rabeprazole sodium for adults is 20 mg once daily. | 25-Mar-21 |
| Raloxifene | 60 | 0.8 | 0.0003 | 1.4 | 5.9 | The recommended dosage is one 60 mg raloxifene hydrochloride tablet daily. | 7-Sep-20 |
| Ramipril | 2.5 | 0.03 | 0.00001 | 0.1 | 0.2 | The usual maintenance dosage range is 2.5 to 20 mg per day administered as a single dose or in two equally divided doses. | 23-Jul-08 |
| Ranitidine | 150 | 1.9 | 0.0006 | 3.5 | 14.8 | The current recommended adult oral dosage for maintenance of healing duodenal ulcers is 150 mg at bedtime. | 24-Nov-21 |
| Rifampin | 600 | 7.5 | 0.003 | 14.0 | 59.2 | For adults, the dosage is 10 mg/kg, in a single daily administration, not to exceed 600 mg/day, orally. | 8-Nov-21 |
| Risperidone | 1 | 0.01 | 0.000004 | 0.02 | 0.1 | Dosage range for bipolar mania in adults is 1 to 6 mg per day. | 31-May-10 |
| Rizatriptan | 5 | 0.1 | 0.00002 | 0.1 | 0.5 | The recommended starting dose of rizatriptan benzoate is either 5 mg or 10 mg for the acute treatment of migraines in adults. The 10 mg dose may provide a greater effect than the 5 mg dose, but may have a greater risk of adverse reactions. | 31-Oct-21 |
| Ropinirole | 0.25 | 0.003 | 0.000001 | 0.006 | 0.02 | The recommended adult starting dose for RLS is 0.25 mg once daily 1 to 3 hours before bedtime. After 2 days, if necessary, the dose can be increased to 0.5 mg once daily. | 15-Sep-21 |
| Rosuvastatin | 5 | 0.1 | 0.00002 | 0.1 | 0.5 | The dose range for rosuvastatin calcium tablets in adults is 5 to 40 mg orally once daily. | 23-Aug-17 |
| Secobarbital | 100 | 1.3 | 0.0004 | 2.3 | 9.9 | For use as a hypnotic, the dosage for adults is 100 mg secobarbital sodium at bedtime. | 31-May-07 |
| Selegiline | 1.25 | 0.02 | 0.000005 | 0.03 | 0.1 | Initiate treatment with 1.25 mg selegiline hydrochloride given once a day for at least 6 weeks. After 6 weeks, the dose may be increased to 2.5 mg given once a day if a desired benefit has not been achieved and the patient is tolerating selegiline hydrochloride. | 1-Jun-21 |
| Sertraline | 25 | 0.3 | 0.0001 | 0.6 | 2.5 | A dosage of 25 mg or 50 mg sertraline hydrochloride per day is the initial therapeutic dosage for adults. Subsequent dosages may be increased in case of an inadequate response in 25 to 50 mg per day increments once a week, depending on tolerability, up to a maximum of 200 mg per day. | 19-Jan-22 |
| Sildenafil | 60 | 0.8 | 0.0003 | 1.4 | 5.9 | The recommended dosage of sildenafil citrate is 20 mg three times a day. Dose may be titrated to a maximum of 80 mg three times a day, if required, based on symptoms and tolerability. | 28-Dec-20 |
| Simvastatin | 20 | 0.3 | 0.000083 | 0.5 | 2.0 | The recommended dosage range of simvastatin tablets is 20 mg to 40 mg once daily. | 13-Oct-20 |
| Sitagliptin | 100 | 1.3 | 0.0004 | 2.3 | 9.9 | The recommended dose of sitagliptin is 100 mg once daily. | 7-Dec-21 |
| Sodium oxybate | 6000 | 75.0 | 0.03 | 139.9 | 591.7 | The recommended starting dose is 4.5 g per night administered orally in two equal, divided doses. Increase the dose by 1.5 g per night at weekly intervals (additional 0.75 g at bedtime and 0.75 g taken 2.5 to 4 hours later) to the effective dose range of 6 g to 9 g per night orally. | 18-Dec-20 |
| Sotalol | 80 | 1.0 | 0.0003 | 1.9 | 7.9 | The starting dose of sotalol hydrochloride tablets (AF) is 80 mg twice daily (b.i.d.) if the creatinine clearance is > 60 mL/min, and 80 mg once daily (q.d.) or 40 mg twice daily (b.i.d) if the creatinine clearance is 40 to 60 mL/min. | 22-Jan-07 |
| Spironolactone ҂ | 25 | 0.3 | 0.0001 | 0.6 | 2.5 | An initial dosage of spironolactone tablets ranging from 25 mg to 100 mg daily is recommended for treatment of essential hypertension. | 22-Aug-18 |
| Sulfadiazine | 2000 | 25.0 | 0.008 | 46.6 | 197.2 | The initial usual adult dosage is 2 g to 4 g. The maintenance dosage is 2 g to 4 g, divided into 3 to 6 doses, every 24 hours. | 30-Jun-20 |
| Sulfamethoxazole | 1600 | 20.0 | 0.007 | 37.3 | 157.8 | Sulfamethoxazole is given in combination with trimethoprim as a tablet (BACTRIM). Each double strength (DS) BACTRIM tablet contains 160 mg trimethoprim and 800 mg sulfamethoxazole. The usual adult dosage in the treatment of urinary tract infections is 1 BACTRIM DS tablet every 12 hours for 10 to 14 days. | 29-Apr-21 |
| Sulfasalazine ҂ | 2000 | 25.0 | 0.008 | 46.6 | 197.2 | Maintenance therapy dosage for adults is 2 g daily. | 10-Feb-21 |
| Sulindac | 300 | 3.8 | 0.001 | 7.0 | 29.6 | In osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, the recommended starting dosage is 150 mg twice a day. The dosage may be lowered or raised depending on the response. | 12-Mar-21 |
| Sumatriptan | 25 | 0.3 | 0.0001 | 0.6 | 2.5 | The recommended dose of sumatriptan tablets is 25 mg, 50 mg, or 100 mg. Doses of 50 mg and 100 mg may provide a greater effect than the 25 mg dose, but doses of 100 mg may not provide a greater effect than the 50 mg dose. Higher doses may have a greater risk of adverse reactions. If the migraine has not resolved by 2 hours after taking sumatriptan tablets, or returns after a transient improvement, a second dose may be administered at least 2 hours after the first dose. The maximum daily dose is 200 mg in a 24-hour period. | 27-Jun-21 |
| Tadalafil | 2.5 | 0.03 | 0.00001 | 0.1 | 0.2 | The recommended starting dose of tadalafil for once daily use is 2.5 mg, taken at approximately the same time every day, without regard to timing of sexual activity. The tadalafil dose for once daily use may be increased to 5 mg, based on individual efficacy and tolerability. | 12-Jun-20 |
| Tamoxifen ҂ | 20 | 0.3 | 0.0001 | 0.5 | 2.0 | For patients with breast cancer, the recommended daily dose of tamoxifen citrate is 20-40 mg. | 20-Apr-07 |
| Tamsulosin | 0.4 | 0.005 | 0.000002 | 0.01 | 0.04 | A dosage of tamsulosin hydrochloride capsules of 0.4 mg once daily is recommended for the treatment of the signs and symptoms of BPH. | 30-Mar-21 |
| Tapentadol | 200 | 2.5 | 0.0008 | 4.7 | 19.7 | Initiate treatment with tapentadol hydrochloride tablets at a dose of 50 mg, 75 mg, or 100 mg every 4 to 6 hours depending upon pain intensity. Subsequent dosing is 50 mg, 75 mg, or 100 mg every 4 to 6 hours and should be adjusted to maintain adequate analgesia with acceptable tolerability. | 7-Dec-18 |
| Telithromycin | 800 | 10.0 | 0.003 | 18.6 | 78.9 | The dose of telithromycin tablets is 800 mg (2 tablets of 400 mg) taken orally once every 24 hours, for 7–10 days. Telithromycin tablets can be administered with or without food. | 2-May-12 |
| Telmisartan | 40 | 0.5 | 0.0002 | 0.9 | 3.9 | The usual starting dose of telmisartan tablets is 40 mg once a day. Blood pressure response is dose-related over the range of 20 to 80 mg. | 1-Jul-20 |
| Temazepam | 7.5 | 0.1 | 0.00003 | 0.2 | 0.7 | While the recommended usual adult dose is 15 mg before retiring, 7.5 mg may be sufficient for some patients, and others may need 30 mg. | 19-Apr-12 |
| Tenofovir | 25 | 0.3 | 0.0001 | 0.6 | 2.5 | The recommended dosage of tenofovir alafenamide is 25 mg (one tablet) taken orally once daily with food. | 21-Sep-21 |
| Terazosin | 1 | 0.01 | 0.000004 | 0.02 | 0.1 | For hypertension, the dose may be slowly increased to achieve the desired blood pressure response. The usual recommended dose range is 1 mg to 5 mg terazosin administered once a day; however, some patients may benefit from doses as high as 20 mg per day. | 18-Aug-21 |
| Terbutaline | 7.5 | 0.1 | 0.00003 | 0.2 | 0.7 | The usual oral dose of terbutaline sulfate for adults is 5 mg administered at approximately six-hour intervals, three times daily, during the hours the patient is usually awake. If side effects are particularly disturbing, the dose may be reduced to 2.5 mg three times daily, and still provide a clinically significant improvement. | 25-Jan-20 |
| Tetracycline | 125 | 1.6 | 0.0005 | 2.9 | 12.3 | Usual daily dose for adults is 1 g as 500 mg twice daily or 250 mg four times a day. In cases of moderate to severe acne which, in the judgement of the clinician, require long-term treatment, the recommended initial dosage is 1 g daily in divided doses. When improvement is noted, dosage should be gradually reduced to maintenance levels ranging from 125 mg to 500 mg daily. | 30-Nov-18 |
| Theophylline | 300 | 3.8 | 0.001 | 7.0 | 29.6 | Starting dose in adults is 300 mg/day; after 3 days increase dose to 400 mg/day if tolerated; and after 3 more days, increase dose to 600 mg/day if tolerated. | 1-Aug-11 |
| Thioridazine | 150 | 1.9 | 0.001 | 3.5 | 14.8 | The usual starting dose for adult schizophrenic patients is 50 mg to 100 mg three times a day, with a gradual increment to a maximum of 800 mg daily if necessary. Once effective control of symptoms has been achieved, the dosage may be reduced gradually to determine the minimum maintenance dose. The total daily dosage ranges from 200 mg to 800 mg, divided into two to four doses. | 16-Sep-19 |
| Thyroxine | 0.128 | 0.002 | 0.000001 | 0.003 | 0.01 | The average full replacement dose of levothyroxine sodium is approximately 1.6 ug/kg-day. (LDD calculated assuming 80 kg adult.) | 1-Jul-20 |
| Ticlopidine | 500 | 6.3 | 0.002 | 11.7 | 49.3 | The recommended dose of ticlopidine hydrochloride is 250 mg b.i.d. taken with food. | 6-Aug-16 |
| Timolol | 20 | 0.3 | 0.0001 | 0.5 | 2.0 | The usual total maintenance dosage of timolol maleate is 20 to 40 mg/day. | 6-Jul-20 |
| Tiotropium bromide | 0.0025 | 0.00003 | 0.00000001 | 0.0001 | 0.0002 | The recommended dosage for patients with asthma is 2 inhalations of tiotropium bromide inhalation spray 1.25 ug per actuation once-daily; total dose equals 2.5 ug of tiotropium bromide. | 19-Jan-22 |
| Tizanidine | 2 | 0.03 | 0.00001 | 0.05 | 0.2 | The recommended starting dose is 2 mg. Dosage can be gradually increased by 2 mg to 4 mg at each dose, with 1 to 4 days between dosage increases, until a satisfactory reduction of muscle tone is achieved. | 11-Aug-17 |
| Topiramate | 100 | 1.3 | 0.0004 | 2.3 | 9.9 | The recommended total daily dose of topiramate capsules (sprinkle) as treatment for patients 12 years of age and older for prophylaxis of migraine headache is 100 mg/day administered in two divided doses. | 29-Nov-21 |
| Tramadol | 100 | 1.3 | 0.0004 | 2.3 | 9.9 | Initiate treatment with tramadol hydrochloride at a dose of 100 mg once daily and titrated up as necessary by 100 mg increments every five days to achieve a balance between relief of pain and tolerability. | 21-May-10 |
| Trazodone | 150 | 1.9 | 0.0006 | 3.5 | 14.8 | An initial dose of 150 mg/day in divided doses is suggested. The dose may be increased by 50 mg/day every 3 to 4 days. Dosage during prolonged maintenance therapy should be kept at the lowest effective level. | 25-Oct-07 |
| Triamterene ҂ | 200 | 2.5 | 0.0008 | 4.7 | 19.7 | Dosage should be titrated to the needs of the individual patient. When used alone, the usual starting dose is 100 mg twice daily after meals. | 20-Aug-21 |
| Trifluoperazine | 2 | 0.03 | 0.000008 | 0.05 | 0.2 | Usual dosage is 1 mg or 2 mg trifluoperazine hydrochloride twice daily. | 29-Aug-19 |
| Trihexyphenidyl | 1 | 0.01 | 0.000004 | 0.02 | 0.1 | The total daily dosage usually ranges between 5 and 15 mg trihexyphenidyl hydrochloride although, in some cases, these reactions have been satisfactorily controlled with as little as 1 mg daily. | 25-Oct-19 |
| Trimethoprim | 200 | 2.5 | 0.001 | 4.7 | 19.7 | The usual oral adult dosage is 100 mg of trimethoprim every 12 hours or 200 mg trimethoprim (two 100 mg tablets) every 24 hours, each for 10 days. | 1-Jan-07 |
| Trimipramine | 50 | 0.6 | 0.0002 | 1.2 | 4.9 | Maintenance therapy is in the range of 50 to 150 mg/day trimipramine maleate. | 30-Jul-20 |
| Valacyclovir | 500 | 6.3 | 0.002 | 11.7 | 49.3 | The recommended dosage of valacyclovir tablets for chronic suppressive therapy of recurrent genital herpes is 1 gram once daily in patients with normal immune function. In patients with a history of 9 or fewer recurrences per year, an alternative dose is 500 mg once daily. | 24-Sep-13 |
| Valproic acid | 800 | 10.0 | 0.003 | 18.6 | 78.9 | For simple and complex absence seizures, the dosage starts at 10 to 15 mg/kg-day, increasing at 1 week intervals by 5 to 10 mg/kg-week until seizure control or limiting side effects. (LDD calculated assuming 80 kg adult.) | 20-Jul-21 |
| Valsartan | 80 | 1.0 | 0.0003 | 1.9 | 7.9 | Valsartan may be used over a dose range of 80 mg to 320 mg daily, administered once a day. | 19-Apr-21 |
| Vancomycin | 500 | 6.3 | 0.002 | 11.7 | 49.3 | For staphylococcal enterocolitis, the total daily dosage is 500 mg to 2 g administered orally in 3 or 4 divided doses for 7 to 10 days. | 8-Feb-22 |
| Vardenafil | 5 | 0.1 | 0.00002 | 0.1 | 0.5 | The vardenafil hydrochloride dose may be increased to a maximum recommended dose of 20 mg or decreased to 5 mg based on efficacy and side effects. The maximum recommended dosing frequency is once per day. | 18-Oct-21 |
| Venlafaxine | 75 | 0.9 | 0.0003 | 1.7 | 7.4 | The recommended starting dose for venlafaxine hydrochloride tablets is 75 mg/day, administered in two or three divided doses, taken with food. | 1-Jul-21 |
| Verapamil | 180 | 2.3 | 0.001 | 4.2 | 17.8 | Initiate therapy with 180 mg of sustained-release verapamil HCI, given in the morning. Lower, initial doses of 120 mg a day may be warranted in patients who may have an increased response to verapamil. | 11-Mar-08 |
| Zidovudine ҂ | 500 | 6.3 | 0.002 | 11.7 | 49.3 | Maternal dosing is 100 mg orally 5 times per day until the start of labor. | 5-Nov-20 |
| Zolpidem | 5 | 0.1 | 0.00002 | 0.1 | 0.5 | Use the lowest effective dose for the patient. The recommended initial dose is 5 mg for women and either 5 or 10 mg for men, taken only once per night immediately before bedtime with at least 7 to 8 hours remaining before the planned time of awakening. If the 5 mg dose is not effective, the dose can be increased to 10 mg. | 10-Sep-19 |