Fluoride Risk Assessment and Relative Source Contribution

Press Release (January 7, 2011)
Fact Sheet: New Fluoride Risk Assessment and Relative Source Contribution Documents (pdf) (24.04 KB, January 2011, EPA 822-F-11-001)

EPA has completed and peer-reviewed a quantitative dose-response assessment based on the available data for severe dental fluorosis as recommended by National Research Council (NRC).

Additional research will be necessary to obtain dose-response data amenable to a quantitative risk assessment for Stage II skeletal fluorosis and, or skeletal fractures. The dose-response assessment provides a reference dose based on the critical health effect of pitting of the enamel in severe dental fluorosis.

• Fluoride: Dose-Response Analysis For Non-cancer Effects (pdf) (1.49 MB, December 2010, EPA 820-R-10-019)
  • Fluoride-Related Skeletal Effects: Evaluations of Key Studies (pdf) (1.94 MB, January 2008, EPA 820-R-10-017)
  • Dental Fluorosis: Evaluations of Key Studies (pdf) (8.45 MB, January 2008, EPA 820-R-10-018)
• Comment-Response Summary Report for the Peer Review of the Fluoride: Dose-Response Analysis for Non-Cancer Effects Document (pdf) (465.28 KB, November 2010, EPA 820-R-10-016)

EPA has also completed and peer-reviewed a document on environmental exposure of children and adults to fluoride and the relative source contribution (RSC) for water. The RSC is needed in order to derive the Maximum Contaminant Level Goal (MCLG) from the dose-response assessment.

• Fluoride: Exposure and Relative Source Contribution Analysis (pdf) (15.42 MB, December 2010, EPA 820-R-10-015)
• Comment-Response Summary Report for the Peer Review of the Fluoride: Exposure and Relative Source Contribution Analysis Document (pdf) (836.26 KB, November 2010, EPA 820-R-10-014)

Other Information or Activities Related to Fluoride

• Information about "Six-Year Reviews" of National Primary Drinking Water Regulations
• Information about food tolerances for sulfuryl fluoride program
• Information on CDC's community water fluoridation program

Please email (ost.comments@epa.gov) comments regarding the documents Fluoride: Dose-Response Analysis For Non-cancer Effects, and Fluoride: Exposure and Relative Source Contribution Analysis to EPA.