Substitutes in Centrifugal Chillers

You will need Adobe Reader to view some of the files on this page. See EPA’s About PDF page to learn more.Substitutes are reviewed on the basis of environmental and health risks, including factors such as ozone depletion potential, global warming potential, toxicity, flammability, and exposure potential. Lists of acceptableThis designation means that a substitute may be used, without restriction, to replace the relevant ODS within the end-use specified. For example, HCFC-22 is an acceptable substitute for R-502 in industrial process refrigeration. Note that all SNAP determinations apply to the use of a specific product as a substitute for a specific ODS in a specific end-use. and unacceptableThis designation means that it is illegal to use a product as a substitute for an ODS in a specific end-use. For example, HCFC-141b is an unacceptable substitute for CFC-11 in building chillers. Note that all SNAP determinations apply to the use of a specific product as a substitute for a specific ODS in a specific end-use. substitutes are updated several times each year. The list of substitutes is shown below.

Note: SNAP-related information published in the Federal Register takes precedence over all information on this page.

Filters              
Substitute Trade Name(s) Retrofit/New ODPA number that refers to the amount of ozone depletion caused by a substance. The ODP is the ratio of the impact on ozone of a chemical compared to the impact of a similar mass of CFC-11. Thus, the ODP of CFC-11 is defined to be 1.0. Other CFCs and HCFCs have ODPs that range from 0.01 to 1.0. The halons have ODPs ranging up to 10. Carbon tetrachloride has an ODP of 1.2, and methyl chloroform's ODP is 0.11. HFCs have zero ODP because they do not contain chlorine. A table of all ozone-depleting substances (http://www.epa.gov/ozone/science/ods/index.html) shows their ODPs, GWPs, and CAS numbers. GWPThe index used to translate the level of emissions of various gases into a common measure in order to compare the relative radiative forcing of different gases without directly calculating the changes in atmospheric concentrations. GWPs are calculated as the ratio of the radiative forcing that would result from the emissions of one kilogram of a greenhouse gas to that from the emission of one kilogram of carbon dioxide over a period of time (usually 100 years). Gases involved in complex atmospheric chemical processes have not been assigned GWPs. See lifetime. ASHRAEASHRAE is an international organization that establishes standards for the uniform testing and rating of heating, ventilation, air conditioning, and refrigeration equipment. It also conducts related research, disseminates publications, and provides continuing education to its members.
Designation
(Safety
Classification)		 SNAP Listing Date Listing Status
Ammonia Absorption   N 0 0 B2 September 5, 1996;
June 16, 2010		 Acceptable
Ammonia Vapor Compression   N 0 0 B2 March 18, 1994 Acceptable
Ammonia Vapor Compression with Secondary Loop   N 0 0 B2 September 5, 1996;
June 16, 2010		 Acceptable
Ammonia / Water Absorption   N 0 0 B2 March 18, 1994 Acceptable
Desiccant Cooling   N 0 N/A N/A March 18, 1994;
June 16, 2010		 Acceptable
Evaporative Cooling   N 0 N/A N/A March 18, 1994;
September 5, 1996
June 16, 2010		 Acceptable
FOR12A FOR12A R/N 0 1,100 A1 December 18, 2000;
December 1, 2016		 Unacceptable in new equipment, except as otherwise allowed under a narrowed use limit, as of January 1, 2024.
FOR12B FOR12B R/N 0 1,000 A1 December 18, 2000;
December 1, 2016		 Unacceptable in new equipment, except as otherwise allowed under a narrowed use limit, as of January 1, 2024.
RB-276 Free Zone, HCFC Blend Delta R/N 0.013 1,592 A1 September 5, 1996 Acceptable
Freeze 12 Freeze 12 R/N 0.013 1,606 A1 September 5, 1996 Acceptable
R-416A FRIGC FR-12, HCFC Blend Beta R/N 0.009 1,081 A1 February 24, 1998 Acceptable
G2018C G2018C R/N 0.053 1,731 A1 September 5, 1996 Acceptable
R-414A GHG-X4, Autofrost, Chill-it, HCFC Blend Xi R/N 0.045 1,478 A1 September 5, 1996 Acceptable
GHG-X5 GHG-X5 R/N 0.032 2,377 A1 June 3, 1997 Acceptable
HCFC-123   R/N 0.02 77 B1 March 18, 1994 Acceptable
HCFC-124   R/N 0.022 609 A1 March 18, 1994 Acceptable
HCFC-22   N 0.055 1,810 A1 March 18, 1994 Acceptable
HCFC-22/HCFC-142b   R/N 0.055-0.065 1,810-2,310 A1 June 3, 1997 Acceptable
HFC-134a   R/N 0 1,430 A1 March 18, 1994;
June 16, 2010;
December 1, 2016		 Unacceptable in new equipment, except as otherwise allowed under a narrowed use limit for military marine vessels and human-rated spacecraft and related support equipment, as of January 1, 2024.
HFC-227ea   N 0 3,220 A1 March 18, 1994;
June 16, 2010;
December 1, 2016		 Unacceptable, except as otherwise allowed under a narrowed use limit, as of January 1, 2024.
HFC-236fa   R/N 0 9,810 A1 February 8, 1996;
December 1, 2016		 Unacceptable in new equipment, except as otherwise allowed under a narrowed use limit, as of January 1, 2024.
HFC-245fa Genetron® 245fa R/N 0 1,030 A1 March 29, 2006;
June 16, 2010;
December 1, 2016		 Unacceptable in new equipment, except as otherwise allowed under a narrowed use limit, as of January 1, 2024.
HFO-1234ze Solstice®  1234ze N 0 6 A2L August 10, 2012 Acceptable
HFO-1336mzz(Z) ((Z)-1,1,1,4,4,4-hexafluorobut-2-ene) Opteon® MZ N 0 9 A1 May 23, 2016 Acceptable
HFO-1336mzz(Z)/dichloroethylene blend (R-514A) Opteon® XP30 R/N 0.00006 7 B1 May 23, 2016 Acceptable
R-414B Hot Shot, Kar Kool, HCFC Blend Omicron R/N 0.098 3,337 A1 September 5, 1996 Acceptable
R-417C Hot Shot 2 R 0 1,820 A1 October 4, 2011 Acceptable
R-515B   N 0 287 A1 December 11, 2020 Acceptable
Ikon A Ikon-12, Blend Zeta N 0 N/A A1 June 19, 2000 Acceptable
Ikon B   R/N 0 N/A A1 December 6, 1999 Acceptable
R-1224yd(Z) AMOLEA™ yd R/N 0.00012 1 A1 November 25, 2019 Acceptable
R-125/R-134a/R-600a (28.1/70.0/1.9) NU-22 old composition R/N 0 1,990 A1 June 16, 2010 Unacceptable in new equipment, except as otherwise allowed under a narrowed use limit, as of January 1, 2024.
R-125/R-290/R-134a/R-600a (55.0/1.0/42.5/1.5) ICOR AT-22 R/N 0 2,530 A1 March 29, 2006;
June 16, 2010		 Unacceptable in new equipment, except as otherwise allowed under a narrowed use limit, as of January 1, 2024.
R-1270 (Propylene)   N 0 1.8 A3 December 1, 2016 Unacceptable as of January 3, 2017.
R-404A SUVA HP-62 R/N 0 3,920 A1 December 20, 2002;
December 1, 2016		 Unacceptable in new equipment, except as otherwise allowed under a narrowed use limit for human-rated spacecraft and related support equipment, as of January 1, 2024.
R-406A GHG-12, GHG-X3, McCool, Autofrost X3 R 0.057 1,900 A2 August 26, 1994 Acceptable
R-407C Suva 407C, Klea 407C R/N 0 1,770 A1 February 8, 1996;
December 20, 2002;
December 1, 2016		 Unacceptable in new equipment, except as otherwise allowed under a narrowed use limit, as of January 1, 2024.
R-410A AZ-20, Suva 9100, Puron N 0 2,090 A1 February 8, 1996;
December 20, 2002;
December 1, 2016		 Unacceptable, except as otherwise allowed under a narrowed use limit, as of January 1, 2024.
R-410B   N 0 2,230 A1 February 8, 1996;
June 16, 2010;
December 1, 2016		 Unacceptable, except as otherwise allowed under a narrowed use limit, as of January 1, 2024.
R-417A ISCEON 59, NU-22 R/N 0 2,350 A1 December 6, 1999;
June 16, 2010;
December 1, 2016		 Unacceptable in new equipment, except as otherwise allowed under a narrowed use limit, as of January 1, 2024.
R-420A Choice R-420A R/N 0.008 1,536 A1 October 1, 2004 Acceptable
R-421A Choice R-421A R/N 0 2,630 A1 September 28, 2006;
June 16, 2010;
December 1, 2016		 Unacceptable in new equipment, except as otherwise allowed under a narrowed use limit, as of January 1, 2024.
R-422B ICOR XAC1, NU-22B R/N 0 2,530 A1 March 29, 2006;
June 16, 2010;
December 1, 2016		 Unacceptable in new equipment, except as otherwise allowed under a narrowed use limit, as of January 1, 2024.
R-422C ICOR XLT1 R/N 0 3,390 A1 March 29, 2006;
June 16, 2010;
December 1, 2016		 Unacceptable in new equipment, except as otherwise allowed under a narrowed use limit, as of January 1, 2024.
R-422D ISCEON MO29 R/N 0 2,730 A1 September 28, 2006;
June 16, 2010;
December 1, 2016		 Unacceptable in new equipment, except as otherwise allowed under a narrowed use limit, as of January 1, 2024.
R-423A ISCEON 39TC R/N 0 2,280 A1 March 22, 2002;
June 16, 2010;
December 1, 2016		 Unacceptable in new equipment, except as otherwise allowed under a narrowed use limit, as of January 1, 2024.
R-424A RS-44 R/N 0 2,440 A1 September 28, 2006;
June 16, 2010;
December 1, 2016		 Unacceptable in new equipment, except as otherwise allowed under a narrowed use limit, as of January 1, 2024.
R-434A RS-45 R/N 0 3,250 A1 October 4, 2007;
June 16, 2010;
December 1, 2016		 Unacceptable in new equipment, except as otherwise allowed under a narrowed use limit, as of January 1, 2024.
R-438A KDD5, ISCEON MO99 R/N 0 2,270 A1 October 4, 2007;
June 16, 2010;
December 1, 2016		 Unacceptable in new equipment, except as otherwise allowed under a narrowed use limit, as of January 1, 2024.
R-443A   N 0 2.5 A3 December 1, 2016 Unacceptable as of January 3, 2017.
R-450A Solstice® N-13 R/N 0 601 A1 October 21, 2014 Acceptable
R-744 (Carbon Dioxide, CO2)   N 0 1 A1 May 23, 2016 Acceptable
R-507, R-507A AZ-50 R/N 0 3,990 A1 September 5, 1996;
December 20, 2002;
December 1, 2016		 Unacceptable in new equipment, except as otherwise allowed under a narrowed use limit, as of January 1, 2024.
R-513A Opteon® XP 10 R/N 0 630 A1 July 16, 2015 Acceptable
RS-44 (2003 formulation)   R/N 0 2,420 A1 June 16, 2010;
December 1, 2016		 Unacceptable in new equipment, except as otherwise allowed under a narrowed use limit, as of January 1, 2024.
Stirling Cycle   N 0 N/A N/A June 16, 2010 Acceptable
THR-02   R/N 0 N/A A1 December 6, 1999 Acceptable
THR-03   N 0 N/A A1 December 6, 1999;
December 1, 2016		 Unacceptable, except as otherwise allowed under a narrowed use limit, as of January 1, 2024.
Trans-1-chloro-3,3,3-trifluoroprop-1-ene Solstice®  1233zd(E), Solstice®  N12 Refrigerant N 0.00024 - 0.00034 4.7 - 7 A1 August 10, 2012 Acceptable
Water / Lithium Bromide Absorption   N 0 0 A1 March 18, 1994;
June 16, 2010		 Acceptable
HFC-32   N 0 675 A2L April 28, 2023 Acceptable with Use Conditions: See rule for detailed conditions.
HFO-1234yf   N 0 <4 A2L April 28, 2023 Acceptable with Use Conditions: See rule for detailed conditions.
R-452B Opteon™ XL55 N 0 698 A2L April 28, 2023 Acceptable with Use Conditions: See rule for detailed conditions.
R-454A Opteon™ XL40 N 0 240 A2L April 28, 2023 Acceptable with Use Conditions: See rule for detailed conditions.
R-454B Opteon™ XL41 N 0 466 A2L April 28, 2023 Acceptable with Use Conditions: See rule for detailed conditions.
R-454C Opteon™ XL20 N 0 148 A2L April 28, 2023 Acceptable with Use Conditions: See rule for detailed conditions.

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Last updated on June 3, 2024