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Toxicology Testing in the 21st Century (Tox21)

Toxicology in the 21st Century (Tox21) is a federal collaboration among EPA, the National Center for Advancing Translational Sciences (NCATS), the National Institute of Environmental Health Sciences (NIEHS), and the Food and Drug Administration (FDA). Tox21 researchers aim to develop better toxicity assessment methods to quickly and efficiently test whether certain chemical compounds have the potential to disrupt processes in the human body that may lead to negative health effects. One of EPA’s contributions to Tox21 are the chemical screening results from the Toxicity Forecaster (ToxCast).

Visit the Tox21 Program webpage to learn more about this collaboration.

Safer Chemicals Research

  • Chemical Evaluation & Characterization
    • High-Throughput Toxicology
    • Rapid Exposure & Dosimetry
    • Emerging Materials and Technology
    • Chemical Characterization and Informatics
  • Complex Systems Science
    • Adverse Outcome Pathways
    • Virtual and Complex Tissue Models
    • Ecotoxicological Assessment and Modeling
  • Translation, Training, & Tools
  • New Approach Methodologies Research
    • NAMs Research
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  • Chemical Research to Inform Decision Making
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Contact Us About Chemical Safety Research
Contact Us to ask a question, provide feedback, or report a problem.
Last updated on May 13, 2025
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