Skip to main content
U.S. flag

An official website of the United States government

Here’s how you know

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

HTTPS

Secure .gov websites use HTTPS
A lock (LockA locked padlock) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

    • Environmental Topics
    • Air
    • Bed Bugs
    • Cancer
    • Chemicals, Toxics, and Pesticide
    • Emergency Response
    • Environmental Information by Location
    • Health
    • Land, Waste, and Cleanup
    • Lead
    • Mold
    • Radon
    • Research
    • Science Topics
    • Water Topics
    • A-Z Topic Index
    • Laws & Regulations
    • By Business Sector
    • By Topic
    • Compliance
    • Enforcement
    • Laws and Executive Orders
    • Regulations
    • Report a Violation
    • Environmental Violations
    • Fraud, Waste or Abuse
    • About EPA
    • Our Mission and What We Do
    • Headquarters Offices
    • Regional Offices
    • Labs and Research Centers
    • Planning, Budget, and Results
    • Organization Chart
    • EPA History

Integrated Science Assessments (ISAs)

  • Scientific Knowledge

    The EPA ISA program is intended to "accurately reflect the latest scientific knowledge useful in indicating the kind and extent of identifiable effects on public health and welfare which may be expected from the presence of pollutant(s) in the ambient air.”

Alert
Alert Notice

[Notice] EPA announced the availability of the Integrated Science Assessment (ISA) for Lead (Final Report) (EPA/600/R-23/375).  [Federal Register Notice February 7, 2024]

EPA sets National Ambient Air Quality Standards (NAAQS) for six criteria air pollutants, which include nitrogen oxides, sulfur oxides, particulate matter, carbon monoxide, ozone and lead. EPA’s Integrated Science Assessments form the scientific foundation for the NAAQS reviews by evaluating and synthesizing the latest science.

  • Carbon Monoxide

    carbon-monoxide

    Read the current Integrated Science Assessment for Carbon Monoxide (CO) which  serves as the scientific foundation for review of the primary and secondary CO NAAQS.

    Carbon Monoxide
  • Lead

    Photo of a child drinking from a water fountain.

    Read the current Integrated Science Assessment for Lead (pb) which serves as the scientific foundation for review of the primary and secondary Pb NAAQS.

    Lead
  • Particulate Matter

    Read the current Integrated Science Assessment for Particulate Matter (PM), which serves as the scientific foundation for review of the primary and secondary PM NAAQS.

    Particulate Matter
  • Ozone

    Read the current Integrated Science Assessment for ozone (O3) and related photochemical oxidants, which serves as the scientific foundation for review of the primary and secondary O3 NAAQS.

    Ozone and Related Photochemical Oxidants
  • Nitrogen Oxides

    Assessment for nitrogen oxides of sulfur and pm, riverbank

    Read the current Integrated Science Assessment for Oxides of Nitrogen (NO2), which serves as the scientific foundation for review of the primary NO2 NAAQS.

    Nitrogen Oxides
  • Sulfur Oxides

    Photo: White smoke coming out of two smokestacks

    Read the current Integrated Science Assessment for Sulfur Oxides (SO2), which serves as the scientific foundation for review of the primary SO2 NAAQS.

    Sulfur Oxides

Basic Information

  • Learn About the ISAs
    • ISA Preamble

Under Review

Call for papers:

  • Aug'23 - O3 ISA Assessment  

Featured Publications

Cover of the Lead Integrated Science Assessment Final Report (2024)

Integrated Science Assessment (ISA) for Lead  (Final Report, 2024)

Related Links

  • What are Criteria Air Pollutants?
  • NAAQS Criteria Pollutants Table
  • Report on the Environment: Air Topic

Calendar of Workshops and Meetings

 RECENT & UPCOMING EVENTS:

  • None at this time. See CASAC meeting calendar for previous meetings and events.

Clean Air Scientific Advisory Committee (CASAC), which provides independent advice to EPA on the technical basis for the NAAQS, is the primarily reviewing authority for the ISAs.

The CASAC Calendar includes a complete list of past and future meeting details.

Calendar

The Preamble to the Integrated Science Assessments, or "Preamble", is an overview document outlining the basic steps and criteria used in developing the Integrated Science Assessments (ISA). Previously included as part of the ISA, it will now be referenced by each ISA as a stand-alone companion document. Learn more about the ISA Preamble.

Contact Us to ask a question, provide feedback, or report a problem.
Last updated on April 21, 2025
  • Assistance
  • Spanish
  • Arabic
  • Chinese (simplified)
  • Chinese (traditional)
  • French
  • Haitian Creole
  • Korean
  • Portuguese
  • Russian
  • Tagalog
  • Vietnamese
United States Environmental Protection Agency

Discover.

  • Accessibility Statement
  • Budget & Performance
  • Contracting
  • EPA www Web Snapshot
  • Grants
  • No FEAR Act Data
  • Plain Writing
  • Privacy
  • Privacy and Security Notice

Connect.

  • Data
  • Inspector General
  • Jobs
  • Newsroom
  • Regulations.gov
  • Subscribe
  • USA.gov
  • White House

Ask.

  • Contact EPA
  • EPA Disclaimers
  • Hotlines
  • FOIA Requests
  • Frequent Questions
  • Site Feedback

Follow.