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  2. CompTox Tools

Computational Toxicology and Exposure APIs

Application Programming Interfaces (APIs) allow programmatic access to the EPA’s computational  toxicology and exposure data resources. APIs provided by EPA enable users to extract specific data from various databases and integrate them into their applications. APIs can effectively automate the process of accessing and downloading the data, such as data used to populate the CompTox Chemicals Dashboard. 

Check out the Computational Toxicology and Exposure API (CTX API) API User Guide for more information on the CTX API development and utility, as well as guidance on how to technically access and use them.

As part of EPA’s commitment to provide “open data”, these CTX APIs are publicly available data resources for anyone to access and use. These APIs are hosted on cloud.gov, a secure cloud environment managed by the General Services Administration specifically for U.S. federal government applications. These data are free of all copyright restrictions, and are fully and freely available for both non-commercial and commercial use. All data are also available for download on the Downloadable Computational Toxicology Data page.

Limited Access APIs

Users need an individual API key to access. Please send an email (ccte_api@epa.gov) to request a FREE API key. 

  • About CTX APIs

    Learn about getting started with CTX APIs.

    About
  • Data Domains

    Learn more about available CTX API data domains.

    Domains
  • Client Packages

    Client API packages have been developed to support access to the CTX APIs.

    Access Clients

CTX API Architecture 

CTX API Architecture Diagram

Disclaimer

The API resources are a compilation of information sourced from many sites, databases and sources, including federal, state, international bodies. The user must apply judgment in use of the information. The user should consult the original scientific paper or data source, if possible, to ensure an understanding of the context of the data.

Reference herein to any specific commercial products, process, or service by trade name, trademark, manufacturer, or otherwise, does not necessarily constitute or imply its endorsement, recommendation, or favoring by the U.S. Government. The views and opinions of the developers of the site expressed herein do not necessarily state or reflect those of the U.S. Government and shall not be used for advertising or product endorsement purposes.

With respect to information available from this server, neither the U.S. Government nor any of their employees, makes any warranty, express or implied, including the warranties of merchantability and fitness for a particular purpose, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights.

CompTox Tools

  • CompTox Tools Home
  • ChemExpo
  • Cheminformatics
  • CompTox Chemicals Dashboard
    • About
    • Dashboard Help
      • Common Navigational Tips
      • Basic Search
      • Product Use Categories Search
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      • List of Assays
      • Lists of Chemicals
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    • Latest News
  • ECOTOX Knowledgebase
  • GenRA
    • About GenRA
    • GenRA Manual
      • Web Application
      • Selecting a Chemical
      • Analogue Identification
      • Data Gap Analysis
      • Analogue Evaluation
      • Read-Across
      • Uncertainty Assessment and Conclusions
      • Other Fingerprint Types
      • User-Defined Neighborhoods
    • Release Notes
  • SeqAPASS
    • User Guide
  • CompTox and Exposure APIs
    • About CTX APIs
    • Data Domains
    • Clients
  • Downloadable Computational Toxicology Data
  • Toxicity Forecasting (ToxCast)
    • Exploring ToxCast Data
    • Generating ToxCast Data
      • Chemical Coverage
      • Chemical Procurement Workflow
Contact Us About CompTox Tools
Contact Us to ask a question, provide feedback, or report a problem.
Last updated on April 29, 2025
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