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  2. Integrated Science Assessments

Integrated Science Assessment (ISA) Ecological Criteria Assessment for Oxides of Nitrogen, Oxides of Sulfur, and Particulate Matter

On this page:

  • Overview
  • History of the Combined Ecological Criteria Assessments
  • Scientific Studies Considered in the ISA
  • Additional Resources

Overview

Cover of the ISA for NOx/SOx/PM Eco Final Assessment

The Integrated Science Assessment for Oxides of Nitrogen, Oxides of Sulfur and Particulate Matter  - Ecological Criteria (Final) provides the U.S. EPA’s evaluation and synthesis of the most policy-relevant science related to the ecological effects of nitrogen oxides, sulfur oxides and particulate matter (PM). This ISA is an update to the 2008 Integrated Science Assessment for Oxides of Nitrogen and Sulfur - Ecological Criteria (Final). Due to the overlap of effects of air pollutants on ecosystems, particulate matter was included in the updated report. In addition, in late 2019 EPA released the Integrated Science Assessment for Particulate Matter (Final Report), which includes the EPA’s evaluation of the policy-relevant science related to human health and other non-ecological aspects of PM effects on welfare (e.g.; visibility and climate). The ISAs provide a comprehensive evaluation and synthesis of the policy-relevant scientific literature, including that published since the last assessment, and serve as the scientific foundation for establishing and reviewing the primary (health-based) and secondary (welfare-based) national ambient air quality standards (NAAQS). 

Oxides of nitrogen or "nitrogen oxides" is a group of highly reactive gases, that also includes nitrogen dioxide (NO2). Oxides of sulfur or “sulfur oxides is a group of highly reactive gases that includes sulfur dioxide (SO2). Particulate matter (PM) is a complex mixture of extremely small particles and liquid droplets suspended in the air. Particulate matter is composed of some or all of the following components: nitrate (NO3−), SO42−, ammonium (NH4+), metals, minerals (dust), and organic and elemental carbon (C). Effects of gaseous oxides of sulfur and nitrogen in the ambient air include injury to leaves and plant physiology. Additionally, both pollutants and PM, contribute to nitrogen and sulfur deposition in ecosystems, which can alter the aquatic and terrestrial biogeochemistry and the physiology of organisms from multiple taxonomic groups. In 2020, the EPA released Integrated Science Assessment (ISA) for Oxides of Nitrogen, Oxides of Sulfur and Particulate Matter Ecological Criteria (Final Report). 

Integrated Science Assessment (ISA) for Oxides of Nitrogen, Oxides of Sulfur and Particulate Matter Ecological Criteria (PDF) (40.86 MB, September 2020, EPA/600/R-20/278)

History of ISAs for these Pollutants 

DateMilestone
Oct 2020EPA released the  Integrated Science Assessment (ISA) for Oxides of Nitrogen, Oxides of Sulfur and Particulate Matter Ecological Criteria (PDF) (40.86 MB, September 2020, EPA/600/R-20/278) . This is the latest version of the NOx, SOx, PM (Ecological) ISA. [Federal Register Notice: Oct 2020]
Dec 2019EPA released the  Integrated Science Assessment for Particulate Matter (PDF) (34.9 MB, December 2019, EPA/600/R-19/188) . [Federal Register Notice: Jan 27, 2020]
Dec 2008EPA released the final report  Integrated Science Assessment for Oxides of Nitrogen and Sulfur Ecological Criteria (PDF) (41.14 MB, December 2008, EPA/600/R-08/082F)
Aug 1993

EPA released the  Air Quality Criteria for Oxides of Nitrogen (Final, 1993) (EPA/600/8-91/049).

  • Air Quality Criteria for Oxides of Nitrogen Volume 1 (PDF) (21.8 MB, August 1993,  EPA600/8-91/049bF)
  • Air Quality Criteria for Oxides of Nitrogen Volume 2 (PDF)  (29.2 MB, August 1993,EPA600/8-91/049bF) 
  • Air Quality Criteria for Oxides of Nitrogen Volume 3 (PDF)  (25.5 MB, August 1993, EPA600/8-91/049cF)
Dec 1982EPA released the Air Quality Criteria for Oxides of Nitrogen (PDF) (Final, 1982) (EPA/600/8-82/026).
Dec 1982

EPA released the document Air Quality Criteria for Particulate Matter and Sulfur Oxides (Final, 1982) (EPA/600/8-82/029).

  • Air Quality Criteria for Particulate Matter and Sulfur Oxides Volume 1 (PDF) (3.6 MB, December 1982, EPA-600/8-82-029a)
  • Air Quality Criteria for Particulate Matter and Sulfur Oxides Volume 2 (PDF) (10.8 MB, December 1982, EPA-600/8-82-029b) 
  • Air Quality Criteria for Particulate Matter and Sulfur Oxides Volume 3 (PDF) (12.3 MB, December 1982, EPA-600/8-82-029c) 
1973EPA released Revised Chapter 5 for Air Quality Criteria for Sulfur Oxides: Effects of Sulfur Oxides in the Atmosphere on Vegetation (PDF) (2.8 MB, September 1973) 
1969The Air Quality Criteria for Sulfur Dioxides (PDF) (12.3 MB, January 1969) was published. 
1967The Air Quality Criteria for Sulfur Oxides (PDF)  (6.0 MB, March 1967) was published. 

Scientific Studies Considered in the ISA

The published studies cited and considered in ISAs are identified in the Health and Environmental Research Online (HERO) database. HERO is a searchable database of more than 1.6 million scientific studies and other references used to develop EPA assessments for understanding the health and environmental effects of pollutants and chemicals. For the most recent final ISA for PM, these are identified on the ISA for NOx/SOx/PM - Ecological Criteria (2020 Final Project Page)

Additional Resources

  • Basic Information About Nitrogen Dioxide Pollution 

  • Basic Information About Sulfur Dioxide Pollution 

  • Basic Information About Particulate Matter Pollution 

  • Secondary National Ambient Air Quality Standards (NAAQS) for Nitrogen Dioxide (NO2) and Sulfur Dioxide (SO2) and Particulate Matter (PM)

  • Technical Documents for NAAQS Reviews  

  • Clean Air Act 

Integrated Science Assessments

  • Learn about ISAs
    • ISA Final Reports
    • ISA preamble
  • Carbon Monoxide
  • Lead
  • Particulate Matter
  • Ozone
  • Nitrogen Oxides
  • Sulfur Oxides
  • Ecological Criteria Assessment
Contact Us About Integrated Science Assessments
Contact Us About Integrated Science Assessments to ask a question, provide feedback, or report a problem.
Last updated on July 16, 2026
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